In:
Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 46, No. 6 ( 1989-12-01), p. 547-555
Abstract:
In this study, we examined the kinetics of host cell infiltration into the nonimmunogenic Colon 26 tumor. We found that 1 x 104 cells were required to produce tumors in 100% of mice. The in vivo doubling time was 42.5 h, and a barely palpable tumor contained 8 x 106 cells. No evidence of concomitant immunity was found. The number of host cells infiltrating the in vivo tumors increased at the same rate as the number of tumor cells, but averaged only 22% of total cells. Cycling T lymphocytes were present in the host cell infiltrate of this tumor. In addition, approximately 50% of in vivo Colon 26 cells were Thy-1.2 positive. The observed characteristic of low immunogenicity makes it a useful murine model for studying human malignant tumors.
Type of Medium:
Online Resource
ISSN:
0741-5400
,
1938-3673
DOI:
10.1002/jlb.46.6.547
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1989
detail.hit.zdb_id:
2026833-6
SSG:
12
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