In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-2), p. e0246366-
Abstract:
Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0246366
DOI:
10.1371/journal.pone.0246366.g001
DOI:
10.1371/journal.pone.0246366.g002
DOI:
10.1371/journal.pone.0246366.g003
DOI:
10.1371/journal.pone.0246366.g004
DOI:
10.1371/journal.pone.0246366.g005
DOI:
10.1371/journal.pone.0246366.g006
DOI:
10.1371/journal.pone.0246366.g007
DOI:
10.1371/journal.pone.0246366.g008
DOI:
10.1371/journal.pone.0246366.t001
DOI:
10.1371/journal.pone.0246366.s001
DOI:
10.1371/journal.pone.0246366.s002
DOI:
10.1371/journal.pone.0246366.s003
DOI:
10.1371/journal.pone.0246366.s004
DOI:
10.1371/journal.pone.0246366.s005
DOI:
10.1371/journal.pone.0246366.s006
DOI:
10.1371/journal.pone.0246366.s007
DOI:
10.1371/journal.pone.0246366.s008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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