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  • 1
    Online Resource
    Online Resource
    Assessment of health-related quality of life in patients with inflammatory bowel disease in occupied Palestinian territory: a correlation cross-sectional study
    Elsevier BV ; 2021
    In:  The Lancet Vol. 398 ( 2021-07), p. S48-
    Details
    In: The Lancet, Elsevier BV, Vol. 398 ( 2021-07), p. S48-
    Type of Medium: Online Resource
    ISSN: 0140-6736
    URL: Article
    DOI: 10.1016/S0140-6736(21)01534-8
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
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    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 2
    Online Resource
    Online Resource
    Women’s awareness of breast cancer symptoms: a national cross-sectional study from Palestine
    Springer Science and Business Media LLC ; 2022
    In:  BMC Public Health Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Public Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: Early diagnosis is crucial to reduce the morbidity and mortality associated with breast cancer (BC). Awareness of BC symptoms plays a key role in this. This study aimed to evaluate the Palestinian women’s awareness of BC symptoms and determine factors associated with good awareness. Methods This was a national cross-sectional study conducted from July 2019 to March 2020 in Palestine. Convenience sampling was used to recruit adult women from hospitals, primary healthcare centers, and public spaces located in 11 governorates. A translated-into-Arabic version of the validated BC awareness measure was utilized for data collection. The awareness level was categorized based on the number of symptoms recognized into: poor (0 to 4), fair (5 to 9), and good (10 to 13). Results Of 6269 approached, 5434 participants completed the questionnaire (response rate = 86.7%). A total of 5257 questionnaires were included in the analysis: 2551 from the Gaza Strip and 2706 from the West Bank and Jerusalem (WBJ). Participants living in the WBJ were more likely to be older, have higher monthly income, and suffer from more chronic diseases than participants living in the Gaza Strip. The most frequently identified BC symptom was ‘lump or thickening in the breast’ ( n  = 4887, 92.9%) followed by ‘lump or thickening under the armpit’ ( n  = 4394, 83.6%). The least frequently identified symptoms were ‘pulling in of the nipple’ ( n  = 2665, 50.7%) and ‘change in the position of the nipple’ ( n  = 2710, 51.6%). A total of 2191 participants (41.7%) demonstrated good awareness of BC symptoms. Participants from the Gaza Strip were more likely than participants from the WBJ to have good awareness (47.0.0% vs. 36.7%). On the multivariable analysis, being ≥ 40 years, completing a post-secondary education, knowing someone with cancer, and visiting hospitals and primary healthcare centers were all associated with an increase in the likelihood of having good awareness. However, living in the WBJ was associated with a decrease in the likelihood of having good awareness. Conclusion Less than half of women included in this study showed good awareness of BC symptoms. More targeted educational interventions are needed to promote Palestinian women’s awareness of BC symptoms to facilitate early diagnosis.
    Type of Medium: Online Resource
    ISSN: 1471-2458
    URL: Article
    DOI: 10.1186/s12889-022-13224-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041338-5
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  • 3
    Online Resource
    Online Resource
    Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years
    MDPI AG ; 2017
    In:  Molecules Vol. 22, No. 10 ( 2017-10-16), p. 1736-
    Details
    In: Molecules, MDPI AG, Vol. 22, No. 10 ( 2017-10-16), p. 1736-
    Abstract: Background: Poor pharmacokinetic profiles and resistance are the main two drawbacks from which currently used antiviral agents suffer, thus make them excellent targets for research, especially in the presence of viral pandemics such as HIV and hepatitis C. Methods: The strategies employed in the studies covered in this review were sorted by the type of drug synthesized into ester prodrugs, targeted delivery prodrugs, macromolecular prodrugs, other nucleoside conjugates, and non-nucleoside drugs. Results: Utilizing the ester prodrug approach a novel isopropyl ester prodrug was found to be potent HIV integrase inhibitor. Further, employing the targeted delivery prodrug zanamivir and valine ester prodrug was made and shown a sole delivery of zanamivir. Additionally, VivaGel, a dendrimer macromolecular prodrug, was found to be very efficient and is now undergoing clinical trials. Conclusions: Of all the strategies employed (ester, targeted delivery, macromolecular, protides and nucleoside analogues, and non-nucleoside analogues prodrugs), the most promising are nucleoside analogues and macromolecular prodrugs. The macromolecular prodrug VivaGel works by two mechanisms: envelope mediated and receptor mediated disruption. Nucleotide analogues have witnessed productive era in the recent past few years. The era of non-interferon based treatment of hepatitis (through direct inhibitors of NS5A) has dawned.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules22101736
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2008644-1
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  • 4
    Online Resource
    Online Resource
    Awareness of Palestinian Women About Breast Cancer Risk Factors: A National Cross-Sectional Study
    American Society of Clinical Oncology (ASCO) ; 2022
    In:  JCO Global Oncology , No. 8 ( 2022-12)
    Details
    In: JCO Global Oncology, American Society of Clinical Oncology (ASCO), , No. 8 ( 2022-12)
    Abstract: This study aimed to assess awareness of Palestinian women about breast cancer (BC) age-related and lifetime risks and its risk factors and to identify factors associated with good awareness. MATERIALS AND METHODS Adult women were recruited from government hospitals, primary health care centers, and public spaces in 11 governorates in Palestine. Recognition of 14 BC risk factors was assessed using a translated-into-Arabic version of the validated BC awareness measure. The level of BC risk factor awareness was determined on the basis of the number of risk factors recognized: poor (0-4), fair (5-9), and good (10-14). RESULTS Of 6,269 potential participants approached, 5,434 agreed and completed the questionnaire (response rate = 86.7%). A total of 5,257 questionnaires were included: 2,706 from the West Bank and Jerusalem and 2,551 from the Gaza Strip. Only 173 participants (3.3%) recognized the age-related risk of BC. More than one quarter (n = 1,465; 27.9%) recognized the lifetime risk of BC. The most recognized modifiable risk factor was not breastfeeding (n = 4,937; 93.9%), whereas the least recognized was having children later on in life or not at all (n = 1,755; 33.4%). The most recognized nonmodifiable risk factor was radiation exposure (n = 4,579; 87.1%), whereas the least recognized was starting the periods at an early age (n = 1,030; 19.6%). In total, 2,024 participants (38.4%) demonstrated good BC risk factor awareness. Participants from the Gaza Strip had a higher likelihood than participants from the West Bank and Jerusalem to have good awareness (42.0% v 35.2%). Age ≥ 40 years, postsecondary education, and visiting hospitals and primary health care centers were all associated with an increase in the likelihood of having good BC risk factor awareness. CONCLUSION The awareness of BC risk factors was suboptimal. These findings highlight the need for implementing health education programs combined with consistent use of ad hoc opportunities to raise awareness by health care providers.
    Type of Medium: Online Resource
    ISSN: 2687-8941
    URL: Article
    DOI: 10.1200/GO.22.00087
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2022
    detail.hit.zdb_id: 3018917-2
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  • 5
    Online Resource
    Online Resource
    Assessment of Health-Related Quality of Life for Patients with Inflammatory Bowel Diseases in Palestine
    The University of Jordan ; 2023
    In:  Jordan Medical Journal Vol. 57, No. 3 ( 2023-08-30)
    Details
    In: Jordan Medical Journal, The University of Jordan, Vol. 57, No. 3 ( 2023-08-30)
    Abstract: Background: Inflammatory bowel disease (IBD) has a significant impact on quality of life (QoL). Disease activity has been suggested as an important indicator for QoL in patients with IBD. The aim of this study was to examine the association between disease activity and patient QoL. Methods: A correlation cross-sectional study was conducted from July 2017 to February 2018. We collected a convenience sample from three major hospitals in southern and northern Palestine. A disease-specific inflammatory bowel disease questionnaire (IBDQ) was used to examine QoL and the results were analyzed using SPSS version 20. Findings: 132 patients were involved in this study. The mean age was 34 years (SD 13) and 77 (58.3%) patients were men. Active disease had been reported in 81 participants (61.4%) in the previous six months. The average IBDQ scores were 150.72  ± 30.08. Emotional and bowel domains were more disrupted than other domains. Active disease was the major significant factor associated with IBD patients’ QoL in all-dimensional scores (p 〈 0.001). Regression analysis revealed that patients in remission (r2 = 0.436, p 〈 0.001), with high educational status (r2 =0.035, p=0.009) and using azathioprine (r2 =0.017, p=0.034) were independently associated with high QoL. Conclusions: This study showed a low QoL among Palestinian IBD patients compared to other countries, and identified a number of significant associated factors that should be considered when dealing with IBD.
    Type of Medium: Online Resource
    ISSN: 2664-8091 , 0446-9283
    URL: Issue
    URL: Article
    DOI: 10.35516/jmj.v57i3
    DOI: 10.35516/jmj.v57i3.1671
    Language: Unknown
    Publisher: The University of Jordan
    Publication Date: 2023
    detail.hit.zdb_id: 2706707-5
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