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  • 1
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    Online Resource
    Stereotactic Radiosurgery and Stereotactic Radiotherapy for Brain Tumors
    Acta Scientific Publications Pvt. Ltd. ; 2021
    In:  Acta Scientific Medical Sciences Vol. 5, No. 9 ( 2021-08-07), p. 12-17
    Details
    In: Acta Scientific Medical Sciences, Acta Scientific Publications Pvt. Ltd., Vol. 5, No. 9 ( 2021-08-07), p. 12-17
    Type of Medium: Online Resource
    ISSN: 2582-0931
    URL: Article
    DOI: 10.31080/ASMS.2020.05.0997
    Language: Unknown
    Publisher: Acta Scientific Publications Pvt. Ltd.
    Publication Date: 2021
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  • 2
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    Značaj respiratornog gejtinga kod simulacije, verifikacije i tretmana karcinoma pluća
    University of Sarajevo Faculty of Health Sciences ; 2022
    In:  Konferencija radioloških tehnoogija s međunarodnim učešćem - CORT
    Details
    In: Konferencija radioloških tehnoogija s međunarodnim učešćem - CORT, University of Sarajevo Faculty of Health Sciences
    Abstract: Već nekoliko decenija, rak pluća najčešći je uzrok oboljevanja i umiranja od malignih tumora širom svijeta. Kako u svijetu tako i u BiH maligne neoplazme danas su visoko rangirane na listi vodećih uzroka smrti u gdje najveći udio u ukupnom broju čine maligne neoplazme bronha i pluća. Karcinom pluća, histološki gledano može se opisati kao bolest, koja ima mnogo podvrsta, te svaka od njih zahtjeva specifičan oblik terapije. Jedna od najprovjerenijih metoda u liječenju raka pluća je radioterapija. Razvoj informatičkih tehnologija doprinio je napretku medicine kao znanstvene grane, posebno u području radioterapije gdje je tehnološki napredak omogućio poboljšanje preciznosti prilikom zračenja malignih tkiva uz bolju kontrolu okolnog zdravog tkiva. Prilagodba radioterapije respiratornim pokretima oduvijek je bila glavna briga u radioterapiji karcinoma grudnog koša. Pokreti prilikom disanja ne utiču samo na pozicioniranje pacijenta tijekom provođenja terapije, već i na pogreške u procesu planiranja liječenja. Kako bi se riješio ovaj problem i reducirala pojava grešaka, već 1990.–ih godina predlaže se upotreba tehnike respiratornog gatinga. 4D – CT kao opcija je poželjan za procjenu tumorske kretnje i individualiziranje ciljnog volumena i njegovih margina. Dimenzija vremena zajedno sa CT-om čini savršenu 4D tehniku koja minimizira utjecaj respiracijskog kretanja tumora i omogućuje lakše ocrtavanje istog. Korist i rasprostranjenost primjene respiratornog gatinga predstavlja prioritet za poboljšanje kvalitete i rezultata radioterapije. Postizanje lokalne kontrole tumora zahtijeva razumijevanje i uključivanje pokreta tumora u simulaciji, planiranju i isporuci tretmana, što dovodi do višestrukih mogućnosti praćenja kretnji targeta. Tehnike respiratornog gajtinga koriste vanjske uređaje za predviđanje faze ciklusa disanja dok pacijent slobodno diše i omogućava isporuku doze samo u određenim fazama disanja. Isporuka snopa zračenja tehnikom respiratornog gatinga namijenjena je kako bi se ograničila ozračenost tumora koji se kreće tokom disanja, na odabrane dijelove respiratornog ciklusa i na taj način omogućava eskalaciju doze i smanjenje doze na rizične organe. Praćenje respiratornog ciklusa zajedno sa četverodimenzionalnim planiranjem pruža opcije kao što su ozračivanje integrisanog tumorskog volumena uz mogućnost aplikovanja zračenja u trenucima udisaja ili izdisaja. Brojna istraživanja predstavljaju tehniku respiratornog gatinga značajnim izazovom, ali i optimalnom tehnikom za liječenje karcinoma pluća uz znatno smanjenje nuspojava i komplikacija radioterapijskog tretmana.
    Type of Medium: Online Resource
    ISSN: 2831-0748 , 2831-073X
    URL: Journal
    URL: Article
    DOI: 10.17532/cort
    DOI: 10.17532/cort.2022.1.11
    Language: Croatian
    Publisher: University of Sarajevo Faculty of Health Sciences
    Publication Date: 2022
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  • 3
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    Differences between biochemical, hematological and coagulation parameters among patients with mild and severe COVID-19
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2023
    In:  Sanamed Vol. 18, No. 1 ( 2023), p. 27-33
    Details
    In: Sanamed, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 18, No. 1 ( 2023), p. 27-33
    Abstract: Introduction: Covid-19 is an infectious disease caused by the severe acute respiratory syndrom coronavirus 2 and causes a series of respiratory symptoms. Considering the appearance and development of symptoms, the course of Covid-19 can go from mild to severe. Depending on the course of Covid-19, the laboratory parameters change a lot, trying to defend the organism against the foreign pathogen and all the changes it causes. Therefore, the aim of this study is to observe the differences between biochemical, hematological and coagulation parameters depending on the disease stage of Covid-19 patients. Material and methods: We conducted cross-sectional study which included 160 Covid-19 patients from Sarajevo, Bosnia and Herzegovina. Biochemical, hematological and coagulation analyzes were performed. Results: Covid-19 patients with a severe clinical course have higher average values of fibrinogen (6.53 ± 4.47, p 〈 0.001), D-dimer (6.89 ± 7.81, p 〈 0.001), APTT (32.05 ± 5.96, p = 0.002), eosinophil (0.66 ± 0.09, p = 0.002) and CRP (93.42 ± 75.86, p = 0.023), and lower values of lymphocytes (1.04 ± 0.98, p 〈 0.001), monocytes (0.45 ± 0.3, p 〈 0.001), compared to Covid-19 patients with a mild clinical course. Covid-19 patients with a severe clinical course had higher average values of neutrophils (10.12 ± 5.80, p = 0.002) and lower values of reactive lymphocytes (0.02 ± 0.03, p 〈 0.001) compared to Covid-19 patients with a mild clinical course. Conclusion: Biochemical, hematological and coagulation parameters can be a sensitive and specific biomarker for distinction of mild and severe Covid-19.
    Type of Medium: Online Resource
    ISSN: 1452-662X , 2217-8171
    Uniform Title: Razlike biohemijskih, hematoloških i koagulacionih parametara među pacijentima sa blagom i teškim oblicima COVID-19
    URL: Article
    DOI: 10.5937/sanamed0-42725
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2023
    detail.hit.zdb_id: 2695960-4
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  • 4
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    INFLUENCE OF COMPUTED TOMOGRAPHY PARAMETERS ON THE RADIOTHERAPY PLAN CALCULATION
    Institute of Knowledge Management (Publications) ; 2022
    In:  KNOWLEDGE - International Journal Vol. 54, No. 4 ( 2022-09-30), p. 603-610
    Details
    In: KNOWLEDGE - International Journal, Institute of Knowledge Management (Publications), Vol. 54, No. 4 ( 2022-09-30), p. 603-610
    Abstract: Contouring, planning and dose calculation in treatment planning systems (TPS) are based on computedtomography (CT) images. Therefore, it is important to have developed, optimized and adapted scanning protocolsfor specific anatomic regions and special radiotherapy modalities such as stereotactic radiosurgery (SRS). The aimof this study was to determine influence of tube voltage, field of view size (FOV) and reconstruction kernels on CTnumbers and the resulting radiotherapy (RT) dose calculation.This study was performed at Clinic of Oncology, Clinical Center University of Sarajevo. Verification electrondensity and CT number values was performed using CIRS Thorax 002LFC phantom, while anthropomorphic CIRS038 phantom for stereotactic end-to-end verification was used for the purpose of dose plan calculation analysis withlarge bore CT simulator Canon Aquillion LB.The significant correlation between the tube voltage and the measuredvalues of CT numbers is significant for all materials (p 〈 0.05), except for water (p = 0.310). No significantcorrelation between FOV and obtained values of CT numbers was found in any of the evaluated tissue equivalentmaterials. Evaluating the impact of reconstruction kernels on Hounsfield units (HU), significant deviations werefound for the FC62, FC68 and FC07 reconstruction kernels. Also, analyzing the influence of reconstruction kernelson the RT dose calculation, the extreme values are associated with Dmin/D in PTV for kernels FC41 and FC68, wheredeviations from the values obtained using the baseline scanning parameters were -1.3% and -1.9%. For deviation of1 HU in muscle tissue of CIRS 002LFC, the calculated Dmin/D in PTV of CIRS STEEV phantom will reduce by0.79%. Similarly, the reduction of D₉₈ and D₂ would be 6.8 cGy and 3.03 cGy for 1 HU, respectively. Change of thereconstruction kernels caused differences of 0.4% in Dmin/D calculation in clinical target volume (CTV).CT scanning and reconstruction parameters may affect Hounsfield units, which could have an impact on dosecalculations in RT plan. Hence, it is recommended to standardize the scanning protocol used in calibration curvegeneration for TPS. One should avoid use of different tube voltages and kernels, while according to this study, thechange of FOV will have no impact on dose calculations
    Type of Medium: Online Resource
    ISSN: 2545-4439 , 1857-923X
    URL: Article
    DOI: 10.35120/kij5404603t
    Language: Unknown
    Publisher: Institute of Knowledge Management (Publications)
    Publication Date: 2022
    detail.hit.zdb_id: 3049213-0
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  • 5
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    Online Resource
    Non-phosphorylated Tyr-1248 form of human epidermal growth factor receptor 2 (HER2) predicts resistance to trastuzumab therapy and poor disease-free survival of HER2-positive breast cancer patients
    Croatian Medical Journals ; 2022
    In:  Croatian Medical Journal Vol. 63, No. 2 ( 2022-4), p. 126-140
    Details
    In: Croatian Medical Journal, Croatian Medical Journals, Vol. 63, No. 2 ( 2022-4), p. 126-140
    Type of Medium: Online Resource
    ISSN: 0353-9504 , 1332-8166
    URL: Article
    DOI: 10.3325/cmj.2022.63.126
    Language: Unknown
    Publisher: Croatian Medical Journals
    Publication Date: 2022
    detail.hit.zdb_id: 2030122-4
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  • 6
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    Acceptance, effects, and tolerability in the vaccination process against SARS-CoV-2 virus among cancer patients in Bosnia and Herzegovina: a single-center cross-sectional study
    Association of Basic Medical Sciences of FBIH ; 2022
    In:  Bosnian Journal of Basic Medical Sciences ( 2022-04-08)
    Details
    In: Bosnian Journal of Basic Medical Sciences, Association of Basic Medical Sciences of FBIH, ( 2022-04-08)
    Abstract: The pandemic of SARS-CoV-2 has been the main health public issue since the end of 2019. Vaccination campaign in B & H started in April 2021 with several vaccines available. Our study aimed to evaluate acceptance, effects and tolerability of vaccines against SARS-COV 2 virus among cancer patients. We have conducted cross-sectional, observational study between 22nd October and 30th November 2021 at the Clinic of Oncology, Clinical Center University of Sarajevo.  Patients were randomly enrolled during their regular visit to the Clinic of Oncology by agreeing to fill in an individual paper questionnaire. The study included 1063 patients with malignant disease of which 681 (64.1%] were fully vaccinated patients. In study population 76.9% of patients reported that they did not have any side effects of vaccination, while only 0.5% of patients had delay in their treatment caused by side effects of vaccination. Among fully vaccinated patients there were 40 patients (3.8%] who were infected with SARS-CoV-2 after the second or booster dose of vaccine. Five patients (0.5%] were hospitalized because of COVID-19 after being fully vaccinated. Findings of our study suggest that cancer patients have higher acceptance of vaccines against SARS-CoV-2 than general population in Bosnia and Herzegovina. Side effects of vaccines are tolerable and do not cause major delay of specific cancer treatment. Protective effects of SARS-CoV-2 vaccines in cancer patients presented in our study are comparable to available results of similar studies which included general population.
    Type of Medium: Online Resource
    ISSN: 1840-4812 , 1512-8601
    URL: Article
    DOI: 10.17305/bjbms.2021.7134
    Language: Unknown
    Publisher: Association of Basic Medical Sciences of FBIH
    Publication Date: 2022
    detail.hit.zdb_id: 2548947-1
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  • 7
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    Availability of technology for managing cancer patients in the Southeast European (SEE) region
    Elsevier BV ; 2022
    In:  Clinical and Translational Radiation Oncology Vol. 34 ( 2022-05), p. 57-66
    Details
    In: Clinical and Translational Radiation Oncology, Elsevier BV, Vol. 34 ( 2022-05), p. 57-66
    Type of Medium: Online Resource
    ISSN: 2405-6308
    URL: Article
    DOI: 10.1016/j.ctro.2022.03.004
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2885426-3
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  • 8
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    Procjena terapijske tačnosti radioterapije karcinoma glave i vrata vođene kompjuterizovanom tomografijom konusnog snopa
    Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina ; 2022
    In:  Radiološke tehnologije Vol. 13, No. 1 ( 2022-12-06)
    Details
    In: Radiološke tehnologije, Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina, Vol. 13, No. 1 ( 2022-12-06)
    Abstract: ABSTRACT Uvod: Karcinom glave i vrata čini 3-5 % svih malignih oboljenja, koji je većinom zastupljen kod muškaraca. Napretkom radioterapije omogućen je optimalniji pristup u liječenju karcinoma glave i vrata, sa poboljšanim ishodom liječenja. Primjena savremenih imidžing tehnika u verifikaciji preciznosti tretmana znatno je promijenila tok radioterapije u liječenju malignih bolesti u smislu eskalacije doze na ciljni volumen uz veću poštedu zdravih struktura. Svrha rada je dokazati značaj i ulogu slikovne verifikacije CBCT imidžing metodom u preciznosti liječenja i kontroli tumora tokom tretmana. Materijal i metode: Istraživanje je provedeno prospektivno u trajanju od 6 mjeseci, na Klinici za onkologiju, Kliničkog centra Univerziteta u Sarajevu. U studiju je uključeno 30 pacijenata sa karcinomom glave i vrata, kod kojih je primjenom slikovne verifikacije CBCT-om uočen gubitak tjelesne težine ili promjena ciljnog volumena. Pacijenti su zračeni VMAT tehnikom na linearnom akceleratoru TrueBeam. Rezultati: Rezultati istraživanja su pokazali da je većina pacijenata bila muškog spola (19), starije životne dobi, sa karcinom larinksa koji je bio prisutan u čak 11 ispitanika. Jači nusefekti bili su prisutni samo kod 3,33% pacijenata, a najzastupljenije neželjene reakcije bile su blaga promuklost, suhoća usta, zamor, otežano gutanje. Od ukupnog broja pacijenata, kod 16 pacijenata uočeno je smanjenje volumena targeta koji je inicijalno prosječno iznosio 80,16 cm3, dok je nakon prosječno 18 frakcija zračenja iznosio 77,58 cm3, što je sigifikanto statistički dokazano (p= 0,007). Utvrđeno je smanjenje volumena lijeve parotidne žlijezde nakon reskeniranja u odnosu na inicijalnu vrijednost (17.37±7.55/16.93±7.06 cm3). Kod svih pacijenata na CBCT volumetrijskim slikama uočen je gubitak tjelesne težine. Zaključak: Radioterapija karcinoma glave i vrata jedan je od učinkovitih modaliteta liječenja, koji moće biti praćen određenim neželjenim reakcijama. Primjena IGRT-a na osnovu kompjuterizirane tomografije konusnog snopa (CBCT), uveliko doprinosi peciznoj isporuci propisane doze zračenja, uz smanjenu toksičnost tretmana. Volumetrijski prikaz anatomskih struktura CBCT metodom, omogućio je da se promijeni tok kursa radioterapije u smislu prilagođavanja PTV margina u toku tretmana, odnosno primjenu adaptivne radioterapije.  
    Type of Medium: Online Resource
    ISSN: 2637-3297 , 2232-8726
    URL: Article
    DOI: 10.48026/issn.26373297.2022.13.1.3
    Language: Unknown
    Publisher: Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina
    Publication Date: 2022
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  • 9
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    Adaptive radiotherapy for head and neck cancer : Adaptivna radioterapija karcinoma glave i vrata
    Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina ; 2020
    In:  Radiološke tehnologije Vol. 11, No. 1 ( 2020-11-07)
    Details
    In: Radiološke tehnologije, Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina, Vol. 11, No. 1 ( 2020-11-07)
    Abstract: Introduction: Radiation therapy has long played an integral role in the manage¬ment of locally advanced head and neck cancer (HNC), both for organ preservation and to improve tumor control in the postoperative setting. The aim of this research is to investigate the effects of adaptive radiotherapy on dosimetric, clinical, and toxicity outcomes for patients with head and neck cancer undergoing radiation therapy treatment. Many sources have reported volume reductions in the primary target, nodal volumes, and parotid glands over treatment, which may result in unintended dosimetric changes affecting the side effect profile and even efficacy of the treatment. Adaptive radiotherapy (ART) is an interesting treatment paradigm that has been developed to directly adjust to these changes.Material and methods: This research contains the results of 15 studies, including clinical trials, randomized prospective and retrospective studies. The researches analyze the impact of radiation therapy on changes in tumor volume and the relationship with planned radiation dose delivery, as well as the possibility of using adaptive radiotherapy in response to identified changes. Also, medical articles and abstracts that are closely related to the title of adaptive radiotherapy were researched.Results: The application of ART significantly improved the quality of life of patients with head and neck cancer, as well as two-year locoregional control of the disease. The average time to apply ART is the middle of the treatment course approximately 17 to 20 fractions of the treatment.Conclusion: Based on systematic review of the literature, evidence based changes in target volumes and dose reduction at OAR, adaptive radiotherapy is recommended treatment for most of the patients with head and neck cancer with the support of image-guided radiotherapy.
    Type of Medium: Online Resource
    ISSN: 2637-3297 , 2232-8726
    URL: Article
    DOI: 10.48026/isnn.26373297.2020.11.1.2
    Language: Unknown
    Publisher: Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina
    Publication Date: 2020
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  • 10
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    Pediatric glioblastoma treated with concurrent radiotherapy and adjuvant Temozolomide: A case study of the treatment of pediatric GBM by the technique of volumetric modulated arc therapy
    Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina ; 2021
    In:  Radiološke tehnologije Vol. 12, No. 1 ( 2021-11-30), p. 38-43
    Details
    In: Radiološke tehnologije, Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina, Vol. 12, No. 1 ( 2021-11-30), p. 38-43
    Abstract: Introduction: Glioblastoma in children (pGBM) occurs somewhat less frequently than in adults. Pediatric pGBMs have a different molecular profile than GBM for adults. The aim of the presentation of this case is the possibility of the effectiveness of the GBM radiation method and the evaluation of magnetic resonance imaging, and the monitoring of the treatment outcome of the patient.Material and methods: The case study is of the retrospective-prospective type. Medical documentation, magnetic resonance imaging, and chronologically monitored evaluation of the findings from November 2018 to August 2021 were used to present the study. The postoperative course was analyzed, as well as the effect of concurrent chemoradiotherapy, VMAT radiotherapy and adjuvant chemotherapy with Temozolomide in a patient aged 4 years and 6 months, comparing treatment outcome with median and overall survival in glioblastoma.Results: The pediatric patient after being diagnosed with high-grade glioma in 2018 is so far in very good general condition, without signs of physical and psycho-social defects, which compared to the scientifically proven median of survival indicates a good therapeutic effect. Volumetrically modulated arc radiotherapy with the use of modern IGRT verification techniques and with the use of chemotherapy with Temozoloimod, has proven to be a still effective oncological method treatment of GBM. For the final outcome of the disease and the effect of therapeutic modalities, the patient's condition and evaluation of magnetic resonance imaging will be monitored. The result supports further research into this therapeutic regimen.Conclusion: Glioblastoma is a very aggressive tumor, which occurs somewhat less frequently in the pediatric population than in adults, but is a very fatal disease. Surgical resection followed by concurrent chemoradiotherapy, with adjuvant Temozolomide is still the method of choice in the treatment of glioblastoma.
    Type of Medium: Online Resource
    ISSN: 2637-3297 , 2232-8726
    URL: Article
    DOI: 10.48026/issn.26373297.2021.12.1.4
    Language: Unknown
    Publisher: Association of Medical Radiology Engineers in Federation of Bosnia and Herzegovina
    Publication Date: 2021
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