In:
American Journal of Reproductive Immunology, Wiley, Vol. 29, No. 1 ( 1993-01), p. 5-16
Abstract:
PROBLEM: There is increasing evidence that decidual lymphocytes play a major role in local interactions at the fetomaternal interface. METHOD: In this paper we use two‐color flow cytometry to delineate the phenotype of lymphocytes obtained from human early decidua by mechanical dispersal technique. RESULTS: The most abundant decidual lymphocytes expressed CD7, CD38, CD56, and CD2 markers, relatively small proportions of CD3 + , CD8 + , CD4 + , CD16 + , CD45RA + , CD11b + , and Leu8 + cells were also present. The vast majority of decidual CD7 + lymphocytes expressed CD38, CD2, and CD56 markers and were CD3 − , CD8 − , CD 16 − , and CD57 − . Decidual CD3 + lymphocytes were weakly staining for TCR α/β, lacked T‐cell receptor (TCR) γ/δ molecules, and ∼40% of them expressed HLA‐DR. All decidual CD8 + lymphocytes were CD2 + and the majority of them expressed CD38, CD56, and CD7 markers and were CD3 − at the same time CD8 + CD7 − lymphocytes were found in decidua. According to the expression of the CD45RA marker, decidual CD8 + lymphocytes could be divided into two subsets: CD8 + CD45RA + CD56 + and CD8 + CD45RA − . CONCLUSIONS: These data clearly demonstrate that decidual lymphocytes display phenotypical features different from those of their counterparts in peripheral blood.
Type of Medium:
Online Resource
ISSN:
1046-7408
,
1600-0897
DOI:
10.1111/aji.1993.29.issue-1
DOI:
10.1111/j.1600-0897.1993.tb00831.x
Language:
English
Publisher:
Wiley
Publication Date:
1993
detail.hit.zdb_id:
2024667-5
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