In:
Annals of the Rheumatic Diseases, BMJ, Vol. 68, No. 4 ( 2009-04), p. 595-598
Abstract:
To assess the possible association of killer immunoglobulin-like receptor ( KIR ) genes, specifically KIR3DL1 , KIR3DS1 and KIR3DL2 , with ankylosing spondylitis (AS). Methods: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the χ 2 test. Results: KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls. Conclusions: Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.
Type of Medium:
Online Resource
ISSN:
0003-4967
,
1468-2060
DOI:
10.1136/ard.2008.095927
Language:
English
Publisher:
BMJ
Publication Date:
2009
detail.hit.zdb_id:
1481557-6
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