GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Publisher
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    The denial of limits and interior aspects of descent
    Emerald ; 2014
    In:  foresight Vol. 16, No. 6 ( 2014-11-10), p. 527-549
    Details
    In: foresight, Emerald, Vol. 16, No. 6 ( 2014-11-10), p. 527-549
    Abstract: – The purposes of this paper are as follows. Part one examines the role of denialism in the context of proposals advanced through the much-abused Limits to Growth (LtG) project. Part two uses three sets of criteria (domains of reality, worldviews and values) to characterise some of the interior human and social aspects of the “denial machine.” It uses these criteria to address some vital, but currently under-appreciated “interior” aspects of descent. (N.B. A succinct “primer” or overview of the concept and underpinning rationale for notions of “descent pathways” is provided in the introduction to this special issue.) Design/methodology/approach – The paper draws on a number of authoritative sources that track the dimensions of global change and, specifically, the ways that humanity is tracking towards Dystopian overshoot-and-collapse futures. The significance of the LtG project is assessed in this context. Part two employs the criteria noted above to identify and open out the centrality of the human and cultural interiors. Findings – Responses to the LtG project are shown to have deprived humanity of the clarity and will to respond effectively to the emerging global emergency. The rise of climate change denialism has followed suit and made effective responses increasingly difficult. A new focus, however, on some of the dynamics of reality domains, worldviews and values, clarifies both the nature of the problem and prefigures a range of solutions, some of which are briefly outlined. Research limitations/implications – This is primarily a conceptual paper that suggests a range of practical responses. For example, re-purposing parts of the current information technology (IT) infrastructure away from financial and economic indices to those tracking the health of the planet. Also translating the case put forward here for a new generation of Institutions of Foresight (IoFs) into real-world start-ups and examples. Further research is needed into the uses and limitations both of positive and negative views of futures. It is suggested that the latter have more value than is commonly realised. Practical implications – In addition to those stated above, the practical implications include new uses for IT infrastructure based on worldcentric – rather than financial and economic worldviews; designing and implementing a new generation of IoFs; and finding new ways to inform the public of impending Dystopian outcomes without exacerbating avoidance and depression. Social implications – The social implications are profound. Currently, humanity has allowed itself to “tune out” and ignore many of the well-founded “signals” (from the global system) and warnings (from those who have observed and tracked real-world changes). As a result, it has outgrown the capacity of the planet to support the current population, let alone the 10 billion currently projected by the United Nations (UN). Something must give. Applied foresight can provide essential lead time to act before human actions are overwhelmed by forces beyond its control. Originality/value – The paper draws together material from hitherto disparate sources to assess the LtG project. It also deploys key concepts from an integral perspective that shed new light on human and cultural forces that determine how people respond to the prospect of Dystopian futures. In so doing, it provides insight into why we are where we are and also into some of the means by which humanity can respond. Specifically, it suggests a shift from collapse narratives to those of descent.
    Type of Medium: Online Resource
    ISSN: 1463-6689
    URL: Article
    DOI: 10.1108/FS-10-2013-0059
    Language: English
    Publisher: Emerald
    Publication Date: 2014
    detail.hit.zdb_id: 2028451-2
    SSG: 25
    SSG: 3,2
    SSG: 3,6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Opinion: Is America “the land of the future”?
    Emerald ; 2008
    In:  Foresight Vol. 10, No. 4 ( 2008-07-18), p. 4-27
    Details
    In: Foresight, Emerald, Vol. 10, No. 4 ( 2008-07-18), p. 4-27
    Abstract: The purpose of this paper is to consider the view that America is “the land of the future”. It argues that, owing to its sponsorship of a model of development that is exploitive and unsustainable, this is no longer the case and that US futurists, in particular, need to consciously re‐evaluate their roles and work. Design/methodology/approach The paper advances a cultural critique of US hegemony. It considers background myths and their role in creating “American exceptionalism” in various fields, including futures studies. It also critiques free market ideology, the role of corporations, market failures and the economics of exploitation. This leads to issues of truth and power and the view that a continuation of an ideology of “free enterprise” leads to the collapse of the global system. Findings The paper suggests a number of strategies for futurists to consider as ways of opening out their vision beyond current limitations. Practical implications A rationale is outlined that can support shifts in more progressive directions and moves toward more fruitful work. Originality/value The American futures enterprise is currently at risk from its uncritical association with dysfunctions in US society, culture and economy. The paper draws attention to some of these and indicates possible ways forward.
    Type of Medium: Online Resource
    ISSN: 1463-6689
    URL: Article
    DOI: 10.1108/14636680810908000
    Language: English
    Publisher: Emerald
    Publication Date: 2008
    detail.hit.zdb_id: 2028451-2
    SSG: 25
    SSG: 3,2
    SSG: 3,6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    The state of play in the futures field: a metascanning overview
    Emerald ; 2009
    In:  Foresight Vol. 11, No. 5 ( 2009-08-28), p. 6-20
    Details
    In: Foresight, Emerald, Vol. 11, No. 5 ( 2009-08-28), p. 6-20
    Abstract: The paper aims to introduce the first iteration of an international research project into the “state of play” in the futures field (SoPiFF) using methodology developed at the Australian Foresight Institute (AFI). Design/methodology/approach The paper outlines the overall approach and the methods it employed, along with some implications and emerging themes from this first iteration. Findings The paper casts new light on patterns of activity in the futures/foresight arena that, in turn, lead to policy questions, including those of purpose and effectiveness. Originality/value The SoPiFF project is of interest not only for its early results, but also for the use of the metascanning methodology outlined here. At one level it draws attention to the nature of the foresight practitioner's toolkit. At another it may also help to guide decisions about future resourcing options and the nature of training that is offered within the domain.
    Type of Medium: Online Resource
    ISSN: 1463-6689
    URL: Article
    DOI: 10.1108/14636680910994932
    Language: English
    Publisher: Emerald
    Publication Date: 2009
    detail.hit.zdb_id: 2028451-2
    SSG: 25
    SSG: 3,2
    SSG: 3,6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Understanding and resolving the global problematique : assessing the balance between progressive and socially conservative foresight
    Emerald ; 2009
    In:  Foresight Vol. 11, No. 5 ( 2009-08-28), p. 21-39
    Details
    In: Foresight, Emerald, Vol. 11, No. 5 ( 2009-08-28), p. 21-39
    Abstract: This paper draws on research undertaken for the State of Play in the Futures Field (SoPiFF) project and aims to explore the contribution of futures work to understanding and resolving aspects of the global problematique and to examine the social interests evident in futures work. Design/methodology/approach The project used an integral meta‐scanning framework to review publicly available futures material. The framework categorizes futures work according to organizational type, social interests, methods, domains and geographic location (details of the methodology are outlined in the accompanying introductory paper as well as on the web site created for the project). Findings The futures field has made a series of significant contributions to understanding the global problematique and has contributed to the pre‐conditions for its resolution. However, the bulk of mainstream futures work does little to improve the preparedness of humanity for looming future crises. More innovative futures work remains marginalized and largely ignored by the powerful and the wider public. There is a strong case for more effective political engagement than has occurred hitherto. Research limitations/implications Further research is needed on shared definitions for the field, interactions with the media, public and other fields of enquiry and action, measurement of individual foresight capacity, strategies for achieving influence – particularly in the political sphere, the role of subcultures within the futures field and suitable publishing strategies. Practical implications The paper recommends specific actions to promote and publicize good work, provide annual digests of futures‐related information, develop and use focused briefings, provide support for “cutting‐edge” futures work, further develop advanced futures methods, create new alliances, build the social capacity for foresight and strengthen the nexus between foresight and philanthropy. Originality/value The paper uses an integral meta‐scanning framework to provide a novel analysis of the futures field. The findings will be of value to all futures and foresight practitioners that are interested in the future success of the field.
    Type of Medium: Online Resource
    ISSN: 1463-6689
    URL: Article
    DOI: 10.1108/14636680910994941
    Language: English
    Publisher: Emerald
    Publication Date: 2009
    detail.hit.zdb_id: 2028451-2
    SSG: 25
    SSG: 3,2
    SSG: 3,6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Descent pathways
    Emerald ; 2014
    In:  foresight Vol. 16, No. 6 ( 2014-11-10), p. 485-495
    Details
    In: foresight, Emerald, Vol. 16, No. 6 ( 2014-11-10), p. 485-495
    Abstract: – The purpose of this special issue is first to highlight the need for wider understanding of the “civilisational challenge” facing humanity, as it encounters and then exceeds significant limits to growth. The second is to present material that provides grounds for developing effective responses. Design/methodology/approach – The issue draws on evidence from previous research, economic modelling and a range of other sources to investigate the hypothesis that humanity is heading towards an “overshoot and collapse” future. It further suggests that a useful way of responding is to explore the possibility that the prospect of collapse can be moderated or avoided through a process of “conscious descent.” Findings – The main findings are that a very wide spectrum of policies, actions, strategies and options is available that can and should be used to help us avoid the most disastrous manifestations of “overshoot and collapse.” Yet there are also many barriers and impediments that continue to inhibit effective responses. This means that the process of coming to grips with the “civilisational challenge” will take longer and become increasingly costly. Denialism and short term thinking remain embedded in dominant institutions and mainstream practice. Currently, vastly more is miss-spent on various perverse incentives (e.g. advertising, the funding of denial, fossil fuel subsidies) than on securing the future of civilisation. This can be seen as a consequence of outdated values and inadequate worldviews. Research limitations/implications – The contributions here represent a sample from within a rapidly expanding field of enquiry and action. They should therefore be seen as indicating the need for further high quality investigation, work and action. The main implication is that this process needs to be taken seriously, properly resourced and eventually transformed into a mainstream social project. Originality/value – The papers are contributions to an in-depth understanding of a complex and evolving situation. Their value lies in the fact that greater understanding and a commitment to early action are among the most productive investments available to societies vulnerable to the systemic threats outlined here. As such, the special issue evokes a fundamental tenet of foresight work in general. Or to put this in the words of Bertrand de Jouvenel, “the proof of improvidence lies in falling under the empire of necessity.”
    Type of Medium: Online Resource
    ISSN: 1463-6689
    URL: Article
    DOI: 10.1108/FS-07-2014-0049
    Language: English
    Publisher: Emerald
    Publication Date: 2014
    detail.hit.zdb_id: 2028451-2
    SSG: 25
    SSG: 3,2
    SSG: 3,6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Mapping the human genetic architecture of COVID-19
    Springer Science and Business Media LLC ; 2021
    In:  Nature Vol. 600, No. 7889 ( 2021-12-16), p. 472-477
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 600, No. 7889 ( 2021-12-16), p. 472-477
    Abstract: The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases 3–7 . They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-021-03767-x
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19 : A Randomized Clinical Trial
    American Medical Association (AMA) ; 2021
    In:  JAMA Vol. 326, No. 17 ( 2021-11-02), p. 1690-
    Details
    In: JAMA, American Medical Association (AMA), Vol. 326, No. 17 ( 2021-11-02), p. 1690-
    Type of Medium: Online Resource
    ISSN: 0098-7484
    URL: Article
    DOI: 10.1001/jama.2021.18178
    RVK:
    XA 10000
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2021
    detail.hit.zdb_id: 2958-0
    detail.hit.zdb_id: 2018410-4
    SSG: 5,21
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19 : A Randomized Clinical Trial
    American Medical Association (AMA) ; 2023
    In:  JAMA Vol. 329, No. 14 ( 2023-04-11), p. 1183-
    Details
    In: JAMA, American Medical Association (AMA), Vol. 329, No. 14 ( 2023-04-11), p. 1183-
    Abstract: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT02735707
    Type of Medium: Online Resource
    ISSN: 0098-7484
    URL: Article
    DOI: 10.1001/jama.2023.4480
    RVK:
    XA 10000
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
    detail.hit.zdb_id: 2958-0
    detail.hit.zdb_id: 2018410-4
    SSG: 5,21
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Whole-genome sequencing reveals host factors underlying critical COVID-19
    Springer Science and Business Media LLC ; 2022
    In:  Nature Vol. 607, No. 7917 ( 2022-07-07), p. 97-103
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 607, No. 7917 ( 2022-07-07), p. 97-103
    Abstract: Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling ( IL10RB and PLSCR1 ), leucocyte differentiation ( BCL11A ) and blood-type antigen secretor status ( FUT2 ). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase ( ATP11A ), and increased expression of a mucin ( MUC1 )—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules ( SELE , ICAM5 and CD209 ) and the coagulation factor F8 , all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-022-04576-6
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19 : A Randomized Clinical Trial
    American Medical Association (AMA) ; 2022
    In:  JAMA Vol. 327, No. 13 ( 2022-04-05), p. 1247-
    Details
    In: JAMA, American Medical Association (AMA), Vol. 327, No. 13 ( 2022-04-05), p. 1247-
    Type of Medium: Online Resource
    ISSN: 0098-7484
    URL: Article
    DOI: 10.1001/jama.2022.2910
    RVK:
    XA 10000
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2022
    detail.hit.zdb_id: 2958-0
    detail.hit.zdb_id: 2018410-4
    SSG: 5,21
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...