In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-1), p. e0278308-
Abstract:
In young adults, overweight and hypertension possibly already trigger cardiac remodeling as seen in mature adults, potentially overlapping non-ischemic cardiomyopathy findings. To this end, in young overweight and hypertensive adults, we aimed to investigate changes in left ventricular mass (LVM) and cardiac volumes, and the impact of different body scales for indexation. We also aimed to explore the presence of myocardial fibrosis, fat and edema, and changes in cellular mass with extracellular volume (ECV), T 1 and T 2 tissue characteristics. We prospectively recruited 126 asymptomatic subjects (51% male) aged 27–41 years for 3T cardiac magnetic resonance imaging: 40 controls, 40 overweight, 17 hypertensive and 29 hypertensive overweight. Myocyte mass was calculated as (100%–ECV) * height 2.7 -indexed LVM. Absolute LVM was significantly increased in overweight, hypertensive and hypertensive overweight groups (104 ± 23, 109 ± 27, 112 ± 26 g) versus controls (87 ± 21 g), with similar volumes. Body surface area (BSA) indexation resulted in LVM normalization in overweights (48 ± 8 g/m 2 ) versus controls (47 ± 9 g/m 2 ), but not in hypertensives (55 ± 9 g/m 2 ) and hypertensive overweights (52 ± 9 g/m 2 ). BSA-indexation overly decreased volumes in overweight versus normal-weight (LV end-diastolic volume; 80 ± 14 versus 92 ± 13 ml/m 2 ), where height 2.7 -indexation did not. All risk groups had lower ECV (23 ± 2%, 23 ± 2%, 23 ± 3%) than controls (25 ± 2%) (P = 0.006, P = 0.113, P = 0.039), indicating increased myocyte mass (16.9 ± 2.7, 16.5 ± 2.3, 18.1 ± 3.5 versus 14.0 ± 2.9 g/m 2.7 ). Native T 1 values were similar. Lower T 2 values in the hypertensive overweight group related to heart rate. In conclusion, BSA-indexation masks hypertrophy and causes volume overcorrection in overweight subjects compared to controls, height 2.7 -indexation therefore seems advisable.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0278308
DOI:
10.1371/journal.pone.0278308.g001
DOI:
10.1371/journal.pone.0278308.g002
DOI:
10.1371/journal.pone.0278308.g003
DOI:
10.1371/journal.pone.0278308.g004
DOI:
10.1371/journal.pone.0278308.t001
DOI:
10.1371/journal.pone.0278308.t002
DOI:
10.1371/journal.pone.0278308.s001
DOI:
10.1371/journal.pone.0278308.s002
DOI:
10.1371/journal.pone.0278308.s003
DOI:
10.1371/journal.pone.0278308.s004
DOI:
10.1371/journal.pone.0278308.s005
DOI:
10.1371/journal.pone.0278308.s006
DOI:
10.1371/journal.pone.0278308.s007
DOI:
10.1371/journal.pone.0278308.s008
DOI:
10.1371/journal.pone.0278308.s009
DOI:
10.1371/journal.pone.0278308.s010
DOI:
10.1371/journal.pone.0278308.s011
DOI:
10.1371/journal.pone.0278308.s012
DOI:
10.1371/journal.pone.0278308.r001
DOI:
10.1371/journal.pone.0278308.r002
DOI:
10.1371/journal.pone.0278308.r003
DOI:
10.1371/journal.pone.0278308.r004
DOI:
10.1371/journal.pone.0278308.r005
DOI:
10.1371/journal.pone.0278308.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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