In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1063, No. 1 ( 2005-12), p. 149-153
Abstract:
A bstract : Coxiella burnetii is the causative agent of Q fever. The bacterium is extremely infectious and is classified as a category biological weapon. A lipopolysaccharide I (LPS I) belongs to the main components of the C. burnetii outer membrane and its structure‐function relationship studies are of potential interest. Size‐exclusion chromatography revealed noticeable differences in distribution and chemical composition of the O‐polysaccharide chains in LPS I. It is likely that C. burnetii is capable of synthesizing chemically distinct subclasses of O‐specific polysaccharide molecules differing in their antigenic reactivities. Methylation‐linkage analysis indicated the presence of terminal virenose (Vir), dihydrohydroxystreptose (Strep), and mannose (Man), 4‐substituted Vir, and 4‐substituted Man in the O‐specific chain. Serological data indicate that Vir and Strep might be involved in the immunobiology of Q fever.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1355.023
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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