In:
Communications Biology, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2021-10-07)
Abstract:
Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo ( N cases = 48,072, N controls = 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL , and TECTA , and a cis -eQTL for ARMC9 . The association of variants in ZNF91 , OTOGL , and OTOP1 was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide significant vertigo variants were associated with hearing loss and only one was associated with age-related hearing impairment. Our results uncovered sequence variants associating with vertigo in a genome-wide association study and implicated genes with known roles in inner ear development, maintenance, and disease.
Type of Medium:
Online Resource
ISSN:
2399-3642
DOI:
10.1038/s42003-021-02673-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2919698-X
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