In:
European Journal of Organic Chemistry, Wiley, Vol. 2016, No. 31 ( 2016-11), p. 5274-5281
Abstract:
An intermolecular approach to the construction of 3,4‐dihydro‐1 H ‐pyrrolo[2,1‐ c ][1,4] oxazines is reported for the first time using the oxa ‐Pictet–Spengler reaction. The method involves a sequence of carbon–carbon‐ and carbon–oxygen‐bond formation between a substituted 2‐(1 H ‐pyrrol‐1‐yl)ethan‐1‐ol and an aldehyde/ketone. p ‐Toluenesulfonic acid ( p TSA) was identified as a suitable catalyst to promote the reaction. The method provides a one‐step conversion of various aldehydes/ketones into the corresponding 3,4‐dihydro‐1 H ‐pyrrolo[2,1‐ c ][1,4] oxazines.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2016.31
DOI:
10.1002/ejoc.201600928
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1410000-9
detail.hit.zdb_id:
1475010-7
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