In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 34, No. 19-20 ( 2020-10-01), p. 1304-1309
Abstract:
Mutations in the estrogen receptor α (ERα) occur in endocrine-resistant metastatic breast cancer. However, a major gap persists with the lack of genetically tractable immune competent mouse models to study disease. Hence, we developed a Cre-inducible murine model expressing a point-activated ESR1 Y541S (ESR1 Y537S in humans) driven by its endogenous promoter. Germline expression of mutant ESR1 Y541S reveals dramatic developmental defects in the reproductive organs, mammary glands, and bones of the mice. These observations provide critical insights into the tissue-specific roles of ERα during development and highlights the potential use of our model in further developmental and cancer studies.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
DOI:
10.1101/gad.339424.120
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2020
detail.hit.zdb_id:
1467414-2
SSG:
12
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