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  • 1
    Online Resource
    Online Resource
    Cervical Metastasis From Squamous Cell Carcinoma of the Maxillary Alveolus and Hard Palate
    Wiley ; 2006
    In:  The Laryngoscope Vol. 116, No. 9 ( 2006-09), p. 1682-1684
    Details
    In: The Laryngoscope, Wiley, Vol. 116, No. 9 ( 2006-09), p. 1682-1684
    Type of Medium: Online Resource
    ISSN: 0023-852X
    URL: Article
    DOI: 10.1097/01.mlg.0000233607.41540.28
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2026089-1
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  • 2
    Online Resource
    Online Resource
    Analysis of Enigma Gene-Signaling Pathways in Thyroid Cancer
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A856-A856
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A856-A856
    Abstract: Fine-needle aspiration (FNA) is one of the most accurate modes of obtaining thyroid nodule biopsies, however, up to 25% of biopsies still yield indeterminate results. There is an increasing number of thyroidectomies due to indeterminate nodules by FNA alone. Therefore, more accurate and time efficient diagnostic approaches for analyzing indeterminate thyroid nodules is required. Recent studies showed that Enigma is associated with different cancer types, including thyroid cancer progression and calcification through its interaction with bone morphogenic protein-1 (BMP-1) and tyrosine kinases linked to mitogen-activated protein kinase (MAPK) signaling pathway. Our published data on Enigma protein analysis with immunohistochemistry showed promising findings to discriminate malignant versus benign nodules. We also showed a thyroid cancer stage-dependent enhancement of Enigma protein expression. In this study, we are investigating Enigma at a gene expression level by quantitative reverse transcription polymerase chain reaction (RT-qPCR), which is more time-efficient, quantitative, and requires less tissue than immunohistochemistry. We extracted mRNA/DNA/proteins from fresh malignant and benign thyroid nodules using a Qiagen AllPrep DNA/RNA/Protein Mini Kit. After verification of the quantity and purity by NanoDrop, isolated mRNA was then run through Enigma-RT-qPCR. MAPK assay was done by western blotting using MAPK-antibody. Our initial results found that Enigma-mRNA expression level was 3-fold higher in malignant compared to benign thyroid tissues. This finding supports our previous protein expression data with a relative quantitative difference in Enigma-mRNA expression level between malignant and benign thyroid nodules. MAPK expression was upregulated in thyroid cancer compared to benign nodules. We conclude that Enigma-RT-qPCR can be used effectively in FNA samples derived from thyroid nodules, which could potentially enhance the diagnostic accuracy of indeterminate nodules and decrease unnecessary thyroidectomies. Furthermore, both Enigma and MAPK were highly expressed in advanced tumor in the same tissues. Future study is needed to establish the functional interaction of Enigma-MAPK activity in thyroid cancer cells.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.1747
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
    detail.hit.zdb_id: 2881023-5
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  • 3
    Online Resource
    Online Resource
    Molecular biology of primary hyperparathyroidism
    Elsevier BV ; 2004
    In:  Otolaryngologic Clinics of North America Vol. 37, No. 4 ( 2004-8), p. 819-831
    Details
    In: Otolaryngologic Clinics of North America, Elsevier BV, Vol. 37, No. 4 ( 2004-8), p. 819-831
    Type of Medium: Online Resource
    ISSN: 0030-6665
    URL: Article
    DOI: 10.1016/j.otc.2004.02.012
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2004
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  • 4
    Online Resource
    Online Resource
    Endoscopic surgery for early glottic carcinoma
    Elsevier BV ; 2003
    In:  Operative Techniques in Otolaryngology-Head and Neck Surgery Vol. 14, No. 1 ( 2003-3), p. 3-11
    Details
    In: Operative Techniques in Otolaryngology-Head and Neck Surgery, Elsevier BV, Vol. 14, No. 1 ( 2003-3), p. 3-11
    Type of Medium: Online Resource
    ISSN: 1043-1810
    URL: Article
    DOI: 10.1016/S1043-1810(03)90034-0
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2003
    detail.hit.zdb_id: 2135189-2
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  • 5
    Online Resource
    Online Resource
    Outcomes of parathyroidectomy for primary hyperparathyroidism with nonlocalizing preoperative imaging
    Wiley ; 2019
    In:  Head & Neck Vol. 41, No. 3 ( 2019-03), p. 666-671
    Details
    In: Head & Neck, Wiley, Vol. 41, No. 3 ( 2019-03), p. 666-671
    Abstract: The purpose of this study was to evaluate our surgical experience in patients with primary hyperparathyroidism (PHPT) with nonlocalizing sestimibi and ultrasound scans. Methods A retrospective review of 521 patients treated from April 2005 to July 2017 at Loma Linda University Medical Center who received parathyroidectomy for PHPT. One hundred forty‐seven patients (28%) had double negative localization (nonlocalizing sestamibi and ultrasound). Results Surgical cure for PHPT was 97.3% and 99.2% with nonlocalized and localized disease, respectively, and complication rates were similar between groups. Preoperative parathyroid hormone and gland weight were significantly lower with nonlocalization. The incidence of multigland disease (MGD) was greater in patients with nonlocalization on sestamibi and ultrasound. Conclusion Nonlocalization of parathyroid glands was not associated with decreased cure rate or increased morbidity. The presence of MGD and requirement for more extensive surgery were greater in patients with nonlocalizing disease.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v41.3
    DOI: 10.1002/hed.25456
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001440-5
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  • 6
    Online Resource
    Online Resource
    Practical Management of Complications in Otolaryngology
    Wiley ; 2013
    In:  Otolaryngology–Head and Neck Surgery Vol. 149, No. S2 ( 2013-09)
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 149, No. S2 ( 2013-09)
    Abstract: Otolaryngologists perform a variety of surgeries, many of which inherently have a small margin for error. While most surgeries are uneventful, complications present special challenges and may create anxiety among surgeons. This miniseminar will employ a multidisciplinary approach to create a paradigm for management of the unwanted surgical complication. A case‐based approach will be used to highlight common complications. Methods for prevention will be reviewed and keys for management of the unwanted complication will be presented. Cases from each otolaryngology subspecialty will be presented with opportunity for audience interaction and questions. Educational Objectives: 1) Recognize common complications within otolaryngology‐head and neck surgery. 2) Evaluate measures that can be taken preoperatively and intraoperatively to prevent complications. 3) Describe methods to manage common complications.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/0194599813493390a30
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2008453-5
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  • 7
    Online Resource
    Online Resource
    Thyroid Surgery in Clinical Practice Guidelines, Consensus Statements, and Position Papers: Content, Interpretation, and Limitations
    Wiley ; 2014
    In:  Otolaryngology–Head and Neck Surgery Vol. 151, No. S1 ( 2014-09)
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 151, No. S1 ( 2014-09)
    Abstract: Key aspects of thyroid surgery have been addressed by published clinical practice guidelines, consensus statements, and position papers from the American Academy of Otolaryngology—Head and Neck Surgery Foundation (AAO‐HSNF), the American Head and Neck Society (AHNS), and the American Thyroid Association (ATA). This miniseminar efficiently presents these society publications, focusing on their content, interpretation, and limitations. Specific topics include surgery for invasive carcinoma, imaging selection, improving postoperative voice outcomes, nerve monitoring, outpatient surgery, and goiter management. These documents will also be used to highlight the important overall differences between practice guidelines, consensus statements, and position papers and their respective influence on clinical decisions. Educational Objectives: (1) Differentiate between a clinical practice guideline, clinical consensus statement, and position paper. (2) Analyze the content, interpretation, and limitations of the key publications sponsored by the AAO‐HNSF, AHNS, and ATA regarding the management of thyroid surgical disease.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/0194599814538403a46
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2008453-5
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  • 8
    Online Resource
    Online Resource
    A Randomized Single‐Blinded Trial of Ibuprofen‐ versus Opioid‐Based Primary Analgesic Therapy in Outpatient Otolaryngology Surgery
    Wiley ; 2019
    In:  Otolaryngology–Head and Neck Surgery Vol. 160, No. 5 ( 2019-05), p. 839-846
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 160, No. 5 ( 2019-05), p. 839-846
    Abstract: To compare the efficacy of pain control and opioid consumption between patients who receive opioid as primary analgesic therapy and those who receive ibuprofen. Study Design Prospective randomized trial. Setting Tertiary care academic hospital. Subject and Methods Adult patients undergoing outpatient otolaryngology surgery were assigned to take hydrocodone/acetaminophen or ibuprofen for postoperative analgesia. Patient‐recorded pain scores and analgesic consumption were analyzed. Results Out of 185 recruits, 108 (58%) completed responses. Fifty‐six patients (52%) received opioid medication for primary analgesic treatment versus 52 (48%) who received ibuprofen. There was no difference in reported pain scores between the treatment groups. Those who received ibuprofen as primary therapy reported a significantly lower consumption of opioid medication at 2.04 tablets/pills (95% CI, 0.9‐3.1) versus 4.86 (3.6‐6.1; P =. 001). Based on multivariate analysis, male sex and older age exhibited lower reported pain scores, while older age and use of ibuprofen as primary therapy exhibited lower opioid requirements. Conclusion For postoperative pain management in outpatient otolaryngology procedures, ibuprofen as primary therapy can provide equally effective pain control as compared with hydrocodone/acetaminophen while decreasing overall opioid requirement. Prescription pill counts are further described to help guide physician practices in the era of an opioid epidemic.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/0194599819832528
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 9
    Online Resource
    Online Resource
    Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups
    MDPI AG ; 2021
    In:  Current Oncology Vol. 28, No. 5 ( 2021-09-19), p. 3610-3628
    Details
    In: Current Oncology, MDPI AG, Vol. 28, No. 5 ( 2021-09-19), p. 3610-3628
    Abstract: Filipino Americans show higher thyroid cancer recurrence rates compared to European Americans. Although they are likely to die of this malignancy, the molecular mechanism has not yet been determined. Recent studies demonstrated that small non-coding RNAs could be utilized to assess thyroid cancer prognosis in tumor models. The goal of this study is to determine whether microRNA (miRNA) signatures are differentially expressed in thyroid cancer in two different ethnic groups. We also determined whether these miRNA signatures are related to cancer staging. This is a retrospective study of archival samples from patients with thyroid cancer (both sexes) in the pathology division from the last ten years at Loma Linda University School of Medicine, California. Deidentified patient demographics were extracted from the patient chart. Discarded formalin-fixed paraffin-embedded tissues were collected post-surgeries. We determined the differential expressions of microRNA in archival samples from Filipino Americans compared to European Americans using the state-of-the-art technique, HiSeq4000. By ingenuity pathway analysis, we determined miRNA targets and the pathways that those targets are involved in. We validated their expressions by real-time quantitative PCR and correlated them with the clinicopathological status in a larger cohort of miRNA samples from both ethnicities. We identified the differentially upregulated/downregulated miRNA clusters in Filipino Americans compared to European Americans. Some of these miRNA clusters are known to target genes that are linked to cancer invasion and metastasis. In univariate analysis, ethnicity and tumor staging were significant factors predicting miR-4633-5p upregulation. When including these factors in a multivariate logistic regression model, ethnicity and tumor staging remained significant independent predictors of miRNA upregulation, whereas the interaction of ethnicity and tumor staging was not significant. In contrast, ethnicity remained an independent predictor of significantly downregulated miR-491-5p and let-7 family. We provide evidence that Filipino Americans showed differentially expressed tumor-tissue-derived microRNA clusters. The functional implications of these miRNAs are under investigation.
    Type of Medium: Online Resource
    ISSN: 1718-7729
    URL: Article
    DOI: 10.3390/curroncol28050309
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2270777-3
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  • 10
    Online Resource
    Online Resource
    Stress-Induced Differential miR-4633-5p Expression in Thyroid Cancer Health Disparities
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A1032-A1032
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A1032-A1032
    Abstract: Filipino Americans (FA) are known to have higher rates of thyroid cancer incidence and disease recurrence compared to European Americans (EA). FA are also known to be two times more likely to die of thyroid cancer compared to EA. Epidemiological studies in California have shown that thyroid cancer is the second most common cancer among FA women. Currently, there are no studies that demonstrate the mechanism behind these discrepancies. Evidence shows a strong correlation between obesity and more aggressive forms of thyroid cancer; obesity has an increased frequency in FA populations. The exact connection between the mechanisms of obesity and cancer is poorly understood. This epigenetic phenomenon may be due to microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dysregulated miRNA profiles have been associated with various diseases including obesity and cancer. MiRNAs are linked to different types of cancer; tumor suppressor genes and oncogenes are subject to modulation by dysregulated miRNAs. No study elucidates the association of miRNAs to tumor staging or prognosis in thyroid cancer health disparities. In this study, we determined miRNA expression profiles and found significant differences in the miRNA profiles between FA and EA thyroid cancer patients. Our pilot study showed several dysregulated miRNAs, from which we chose to assay dysregulated miR-4633-5p segments that are known to be associated with thyroid cancer signaling. We used QIAGEN’s miRNA extraction kit to obtain high-quality miRNA from paraffin-embedded thyroid tissues. We performed next-generation miRNA sequencing using equal number of FA and EA samples and identified the top ten significantly up- and down-regulated miRNAs from the pool of differentially expressed miRNAs by qPCR assays. Our investigation demonstrated a 1.5-2-fold higher expression of an upregulated miR-4633-5p in FA versus EA miRNA samples (n=70) after normalized to controls. In contrast, miR-323b-3p showed no difference between FA and EA after normalized to controls. For our future work, we plan to analyze multiple up- and down-regulated miRNAs by qPCR, determine whether the miRNA signatures are consistent between samples from FA versus EA, and explore the use of these miRNA signature differentials for affordable and rapid thyroid cancer screening and prognosis.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.2112
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
    detail.hit.zdb_id: 2881023-5
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