In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 7 ( 2021-7-1), p. e0253892-
Abstract:
Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures. Objective To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight. Method A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx). Results The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = 〈 .000), and S-CTx (r = -0.53838; p = 0.011) in girls. Conclusion Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0253892
DOI:
10.1371/journal.pone.0253892.t001
DOI:
10.1371/journal.pone.0253892.t002
DOI:
10.1371/journal.pone.0253892.t003
DOI:
10.1371/journal.pone.0253892.t004
DOI:
10.1371/journal.pone.0253892.t005
DOI:
10.1371/journal.pone.0253892.s001
DOI:
10.1371/journal.pone.0253892.s002
DOI:
10.1371/journal.pone.0253892.s003
DOI:
10.1371/journal.pone.0253892.s004
DOI:
10.1371/journal.pone.0253892.s005
DOI:
10.1371/journal.pone.0253892.r001
DOI:
10.1371/journal.pone.0253892.r002
DOI:
10.1371/journal.pone.0253892.r003
DOI:
10.1371/journal.pone.0253892.r004
DOI:
10.1371/journal.pone.0253892.r005
DOI:
10.1371/journal.pone.0253892.r006
DOI:
10.1371/journal.pone.0253892.r007
DOI:
10.1371/journal.pone.0253892.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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