In:
Biochemical Society Transactions, Portland Press Ltd., Vol. 40, No. 4 ( 2012-08-01), p. 698-703
Abstract:
We describe our efforts to combine in vitro enzymatic reactions with recombinant kinases to phosphorylate the neuronal tau protein, and NMR spectroscopy to unravel the resulting phosphorylation pattern in both qualitative and quantitative manners. This approach, followed by functional assays with the same samples, gives access to the complex phosphorylation code of tau. As a result, we propose a novel hypothesis for the link between tau (hyper)phosphorylation and aggregation.
Type of Medium:
Online Resource
ISSN:
0300-5127
,
1470-8752
Language:
English
Publisher:
Portland Press Ltd.
Publication Date:
2012
SSG:
12
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