In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 8 ( 2023-8-22), p. e0290223-
Abstract:
Prime objective of the current research was to develop a stable nimesulide emulgel with the help of arabinoxylan, a natural gelling agent extracted from Plantago ovata. The response surface methodology was used by a Design Expert 10 software to formulate and optimize the emulgel. The experimental design approach evaluated the impact of independent and dependent variables. Independent variables were different concentrations of arabinoxylan, span 80 and tween 20, whereas, dependent variables were viscosity, pH, and content uniformity. FTIR demonstrated the compatibility of nimesulide with the excipients. Stability study indicated no phase separation and no change in pH for formulation F1, F3 and F4. The negative values of zeta potential revealed the excellent stability of emulgel. Viscosity, spreadability and extrudability values were in desired range. Ex-vivo permeation study illustrated 86%, 55% and 66% release of the drug over a period of 24 h from the formulations F1, F3 and F4, respectively. Analgesic effect of the optimized emulgel was significantly higher in test group as compared to control and did not produce any sort of irritation. Therefore, it can be concluded that the newly developed emulgel based on arabinoxylan, as gelling agent, appear to be an effective drug delivery system.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0290223
DOI:
10.1371/journal.pone.0290223.g001
DOI:
10.1371/journal.pone.0290223.g002
DOI:
10.1371/journal.pone.0290223.g003
DOI:
10.1371/journal.pone.0290223.g004
DOI:
10.1371/journal.pone.0290223.g005
DOI:
10.1371/journal.pone.0290223.g006
DOI:
10.1371/journal.pone.0290223.g007
DOI:
10.1371/journal.pone.0290223.g008
DOI:
10.1371/journal.pone.0290223.g009
DOI:
10.1371/journal.pone.0290223.t001
DOI:
10.1371/journal.pone.0290223.t002
DOI:
10.1371/journal.pone.0290223.t003
DOI:
10.1371/journal.pone.0290223.t004
DOI:
10.1371/journal.pone.0290223.t005
DOI:
10.1371/journal.pone.0290223.t006
DOI:
10.1371/journal.pone.0290223.t007
DOI:
10.1371/journal.pone.0290223.s001
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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