In:
FEBS Letters, Wiley, Vol. 194, No. 1 ( 1986-01), p. 131-138
Abstract:
The sequences of Saccharomyces cerevisiae mitochondrial tRNA 1 Arg , tRNA 2 Arg , tRNA Gly , tRNA 2 Lys tRNA Leu and tRNA Pro are reported. Special structural features were found in tRNA Pro , which has A 8 , C 21 , A 48 instead of the constant residues U 8 , A 21 and pyrimidine 48, and in tRNA 2 Lys , which has a U excluded from basepairing and bulging out from the TΨC stem. The tRNA 1 Arg , tRNA 2 Lys and tRNA Leu , which belong to two‐codon families ending in a purine, have a modified uridine in the wobble position, which prevents misreading of C and U. It is likely to be 5‐carboxymethylaminomethyluridine. tRNA Gly and tRNA Pro have an unmodified uridine in the wobble position allowing the reading of all four codons of a four‐codon family. However, tRNA 2 Arg , which is a minor species and belongs to the CGN four‐codon family, has an unmodified A in the wobble position. This very unusual feature raises the problem of the mechanism by which the codons CGA, CGG and CGC are recognized.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(86)80064-3
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
1460391-3
SSG:
12
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