In:
Chemistry & Chemical Technology, Lviv Polytechnic National University, Vol. 17, No. 2 ( 2023-06-01), p. 294-303
Abstract:
Conjugated heterocyclic compounds with a 1,2,4-triazole core are of scientific interest due to their wide application in both synthetic and medicinal chemistry. In this review, we comprehensively summarize the synthetic methods for [1,2,4]triazolo[1,5-a] pyridine-8-carbonitriles. The methods are classified as follows: convertion of 8-substituted [1,2,4]triazolo[1,5-a] pyridines; synthesis based on functionalized pyridines, containing a nitrile group; synthesis based on heterocyclization of 2-(1,2,4-triazol-5-yl)acetonitriles, including cyclocondensation of 2-(1,2,4-triazol-5-yl)acetonitriles with β-dicarbonyl compounds and heterocyclization of 2-(1,2,4-triazol-5-yl)acetonitriles with α,β-unsaturated nitriles and esters; cyclocondensation of acyclic reagents, namely hydrazine derivatives and substituted methylenemalononitriles or their precursors and recyclization of oxadiazolopyridi-nium salts upon the interaction with ammonia or amine.
Type of Medium:
Online Resource
ISSN:
1996-4196
,
1996-4196
Uniform Title:
Strategies for the Synthesis of [1,2,4]Triazolo[1,5-a]pyridine-8-carbonitriles
DOI:
10.23939/chcht17.02.294
Language:
Unknown
Publisher:
Lviv Polytechnic National University
Publication Date:
2023
detail.hit.zdb_id:
2735863-X
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