In:
Circulation: Cardiovascular Quality and Outcomes, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. suppl_2 ( 2015-05)
Abstract:
Background: We sought to examine the relationship between gender, age, co-morbidities, and outcomes in patients with non-hemorrhagic stroke. Materials and methods: Retrospective chart review was performed on 517 consecutive non-hemorrhagic stroke patients (48% women, 20% with diabetes, 26.8% with CAD, 38% with dyslipidemia, 62.2% with HTN, 4.2% with peripheral vascular disease, 4.7% with renal insufficiency) treated at a single academic medical center. Results: Younger patients were more likely to be men (age 〈 50 55%, 51-60 58.3%, 61-70 59.6%; p 〈 0.05) while older patients were likely to be women (age 71-80 54.9%, 〉 80 56.6; p 〈 0.05). Accordingly, the subsequent analysis stratified the cohort into two groups, 〈 70 and 〉 70 years old. Regardless of age, men had a higher prevalence of CAD (age 〈 70, 25.2% vs 18.8% in women, and age 〉 70, 43.7% vs. 23.1% in women; p 〈 0.05) and dyslipidemia (age 〈 70, 43.4% vs 32.5% in women and age 〉 70, 44.8% vs. 30.6% in women; p=.05). There were no significant gender based differences in BMI, prevalence of diabetes, hypertension, peripheral vascular disease, or chronic renal insufficiency. The mean follow up duration was 47.3+/-0.9 months. Gender did not affect mortality in patients younger than 70 years old (15.5% men vs. 15.6% women.) However in patients of age 〉 70 mortality was significantly increased in men (50.5% in men vs. 41.7% in women; chi-squared p 〈 0.001, log-rank p 〈 0.0001, Figure). In logistic regression analysis, when compared to women younger than 70 years old, men of the same age had similar mortality (HR 1.0; 95%CI 0.5-1.9, p=0.980); while age greater than 70 conferred 4-5 fold increased risk of mortality (HR 3.9; 95%CI 2.1-7.0, p 〈 0.0001 in women, and HR 5.5; 95%CI 3.0-10.3, p 〈 0.0001 in men). When gender and age were accounted for, history of coronary artery disease and/or dyslipidemia did not affect the outcomes. Conclusion: Men with non-hemorrhagic stroke were more likely to have dyslipidemia and history of coronary artery disease. This, however, did not translate into increased mortality in younger men. Gender appears to have a differential effect on non-hemorrhagic stroke outcomes which warrants future investigation.
Type of Medium:
Online Resource
ISSN:
1941-7713
,
1941-7705
DOI:
10.1161/circoutcomes.8.suppl_2.101
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2015
detail.hit.zdb_id:
2453882-6
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