In:
FEBS Letters, Wiley, Vol. 594, No. 12 ( 2020-06), p. 1960-1973
Abstract:
The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID‐19) caused by the novel coronavirus SARS‐CoV‐2 a pandemic. There is, however, no confirmed anti‐COVID‐19 therapeutic currently. In order to assist structure‐based discovery efforts for repurposing drugs against this disease, we constructed knowledge‐based models of SARS‐CoV‐2 proteins and compared the ligand molecules in the template structures with approved/experimental drugs and components of natural medicines. Our theoretical models suggest several drugs, such as carfilzomib, sinefungin, tecadenoson, and trabodenoson, that could be further investigated for their potential for treating COVID‐19.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.v594.12
DOI:
10.1002/1873-3468.13806
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1460391-3
SSG:
12
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