In:
Alzheimer's & Dementia, Wiley, Vol. 16, No. S4 ( 2020-12)
Abstract:
Previous studies investigating potential beneficial effects of Omega‐3 Polyunsaturated Fatty Acids (PUFA) on vascular health have shown inconsistent results. Oxylipins, produced from the oxidation of PUFAs, have potent vascular effects shown to be relevant to human disease. We have previously reported the cytochrome P450‐derived Omega‐3 PUFA Docosahexaenoic acid (DHA) oxylipin 16,17‐EpDPE to be associated with less cerebral white matter hyperintensities (WMH), while a ratio of its soluble epoxide hydrolase (sEH) products, 19,20‐DiHDPE/19,20‐EpDPE were associated with higher WMH. Relationships between DHA and its oxylipin products and microstructural white matter integrity is unknown. Method 36 cognitively intact subjects with low blood omega‐3 levels, controlled hypertension, 55 years or older, enrolled in a study investigating fish oil and lipoic acid on preserving cognitive function, underwent baseline MRI and plasma PUFA oxylipins measured by liquid chromatography tandem mass spectrometry. Voxel‐wise associations between Diffusion Tensor Imaging (DTI) metrics, including fractional anisotropy (FA), radial (RD) and axial (AD) diffusivity, and DHA and oxylipins were examined using Tract‐Based Spatial Statistics, adjusted for age and sex. Result Higher DHA oxylipin 16, 17‐EpDPE was associated with increased FA clusters within the inferior frontal‐occipital fasciculus, and the cingulate and anterior thalamic radiation tracts. Higher DHA oxylipin ratio 19, 20‐DiHDPE/19, 20‐EpDPE was associated with decreased FA in those same regions, as well as in the superior and inferior longitudinal fasciculi and corticospinal tract. Increased RD clusters were observed in some corresponding regions in relation to 19, 20‐DiHDPE/19, 20‐EpDPE. DHA was not related to DTI measures. Conclusion The oxylipin 16,17‐EpDPE, an epoxide, is associated with greater DTI white matter integrity, while a ratio of 19,20‐DiHDPE/19,20‐EpDPE , is associated with decreased DTI white matter integrity, in a hypertensive young‐old cohort. Protective epoxides are converted to diols by sEH, the ratio of diol/epoxide is an indirect measure of sEH activity. Affected areas were found largely in long‐range association fibers, important for intrahemispheric cortical connectivity, with extension beyond areas of macrostructural WMH lesions. DHA‐derived cytochrome P450 oxylipins, not DHA, are associated with DTI white matter integrity with differential effects observed. Targeting specific DHA oxylipin products is warranted for the effective prevention of cerebrovascular disease.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2201940-6
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