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  • 1
    Online Resource
    Online Resource
    The Korean Society of Anesthesiologists ; 2021
    In:  Anesthesia and Pain Medicine Vol. 16, No. 3 ( 2021-07-31), p. 305-311
    In: Anesthesia and Pain Medicine, The Korean Society of Anesthesiologists, Vol. 16, No. 3 ( 2021-07-31), p. 305-311
    Abstract: Background: The STOP-BANG questionnaire is a simple screening tool with high sensitivity for the detection of severe obstructive sleep apnea (OSA). Predicting airway obstruction would allow the safe management of sedative patients to prevent intraoperative hypoxia. This study was designed to check the correlation between the STOP-BANG score and oxygen saturation (SpO2) during sedation and confirm the availability of the STOP-BANG questionnaire as a preoperative exam for predicting the incidence of hypoxia in sedative patient management.Methods: This study included 56 patients who received spinal anesthesia. The pre-anesthesia evaluation was conducted using the STOP-Bang questionnaire. The patients were under spinal anesthesia with an average block level of T10. Dexmedetomidine was infused with a loading dose of 1 μg/kg over 10 min and a maintenance dose of 0.5 μg/kg/h until the end of the procedure. The SpO2 of the patients was recorded every 5 min.Results: The STOP-Bang score was negatively correlated with the lowest SpO2 (coefficient = –0.774, 95% confidence interval [CI]: –0.855 to –0.649, standard error [SE] = 0.054, P 〈 0.001). The item of “observed apnea” was the most correlated one with hypoxic events (odds ratio = 6.00, 95% CI: 1.086 to 33.145).Conclusions: The STOP-BANG score was significantly correlated with the lowest SpO2 during spinal anesthesia, which enabled the prediction of meaningful hypoxia before it occurred in the sedated patients.
    Type of Medium: Online Resource
    ISSN: 1975-5171 , 2383-7977
    Language: English
    Publisher: The Korean Society of Anesthesiologists
    Publication Date: 2021
    detail.hit.zdb_id: 3155687-5
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  • 2
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: Mucus secretion is often uncontrolled in many airway inflammatory diseases of humans. Identifying the regulatory pathway(s) of mucus gene expression, mucus overproduction, and hypersecretion is important to alleviate airway inflammation in these diseases. However, the regulatory signaling pathway controlling mucus overproduction has not been fully identified yet. In this study, we report that the ATP/P2Y 2 complex secretes many cytokines and chemokines to regulate airway inflammation, among which IL-1 receptor antagonist (IL-1ra) downregulates MUC5AC gene expression via the inhibition of G α q-induced Ca 2+ signaling. IL-1ra inhibited IL-1 α protein expression and secretion, and vice versa. Interestingly, ATP/P2Y 2 -induced IL-1ra and IL-1 α secretion were both mediated by PLC β 3. A dominant-negative mutation in the PDZ-binding domain of PLC β 3 inhibited ATP/P2Y 2 -induced IL-1ra and IL-1 α secretion. IL-1 α in the presence of the ATP/P2Y 2 complex activated the ERK1/2 pathway in a greater degree and for a longer duration than the ATP/P2Y 2 complex itself, which was dramatically inhibited by IL-1ra. These findings suggest that secreted IL-1ra exhibits a regulatory effect on ATP/P2Y 2 -induced MUC5AC gene expression, through inhibition of IL-1 α secretion, to maintain the mucus homeostasis in the airway. Therefore, IL-1ra could be an excellent modality for regulating inflamed airway microenvironments in respiratory diseases.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2008065-7
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  • 3
    Online Resource
    Online Resource
    The Korean Society of Anesthesiologists ; 2019
    In:  Korean Journal of Anesthesiology Vol. 72, No. 2 ( 2019-04-01), p. 164-168
    In: Korean Journal of Anesthesiology, The Korean Society of Anesthesiologists, Vol. 72, No. 2 ( 2019-04-01), p. 164-168
    Type of Medium: Online Resource
    ISSN: 2005-6419 , 2005-7563
    Language: English
    Publisher: The Korean Society of Anesthesiologists
    Publication Date: 2019
    detail.hit.zdb_id: 2557340-8
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  • 4
    Online Resource
    Online Resource
    The Korean Society of Anesthesiologists ; 2020
    In:  Anesthesia and Pain Medicine Vol. 15, No. 2 ( 2020-04-30), p. 241-246
    In: Anesthesia and Pain Medicine, The Korean Society of Anesthesiologists, Vol. 15, No. 2 ( 2020-04-30), p. 241-246
    Abstract: Background: Postoperative pain is affected by preoperative depression. If the risk of postoperative pain associated with depression can be predicted preoperatively, anesthesiologists and/or surgeons can better manage it with personalized care. The objective of this study was to determine the efficacy of Patient Health Questionnaire-2 (PHQ-2) depression screening tool as a predictor of postoperative pain. Methods: A total of 50 patients scheduled for elective laparoscopic cholecystectomy with an American Society of Anesthesiologists grade of 1 or 2 were enrolled. They answered the PHQ-2, which consists of two questions, under the supervision of a researcher on the day before the surgery. The numerical rating scale (NRS) scores were assessed at post-anesthesia care unit (PACU), at 24, and 48 postoperative hours, and the amount of intravenous patient-controlled analgesia (IV-PCA) administered was documented at 24, 48, and 72 postoperative hours. At 72 h, the IV-PCA device was removed and the final dosage was recorded.Results: The NRS score in PACU was not significantly associated with the PHQ-2 score (correlation coefficients: 0.13 [P = 0.367]). However, the use of analgesics after surgery was higher in patients with PHQ-2 score of 3 or more (correlation coefficients: 0.33 [P = 0.018] ).Conclusions: We observed a correlation between the PHQ-2 score and postoperative pain. Therefore, PHQ-2 could be useful as a screening test for preoperative depression. Particularly, when 3 points were used as the cut-off score, the PHQ-2 score was associated with the dosage of analgesics, and the analgesic demand could be expected to be high with higher PHQ-2 scores.
    Type of Medium: Online Resource
    ISSN: 1975-5171 , 2383-7977
    Language: English
    Publisher: The Korean Society of Anesthesiologists
    Publication Date: 2020
    detail.hit.zdb_id: 3155687-5
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  • 5
    Online Resource
    Online Resource
    Kosin University College of Medicine ; 2017
    In:  Kosin Medical Journal Vol. 32, No. 2 ( 2017-12-31), p. 164-169
    In: Kosin Medical Journal, Kosin University College of Medicine, Vol. 32, No. 2 ( 2017-12-31), p. 164-169
    Abstract: Controlling pain in cancer patients is important for several reasons including patient quality of life (QOL). In moderate-to-severe cancer-pain management, opioid analgesics are indispensable. Among these, morphine is the most representative. Unfortunately, many studies have shown that morphine is potentially associated with cancer growth, recurrence, and metastasis. Specifically, in animal as well as in vivo and in vitro studies, morphine has been demonstrated to have possibly positive effects on cancer progression. However, those effects have not yet been confirmed as entirely harmful, for several reasons: the results of animal and laboratory research have not been subjected to clinical trials; there are as yet no well-designed clinical studies, and indeed, some studies have shown that morphine can have negative, suppression effects on tumor growth. This review paper will present some of the data on the potentially positive relationships between morphine and cancer. It should not be forgotten, though, that such relationships remain controversial, and that pain itself promotes cancer progression.
    Type of Medium: Online Resource
    ISSN: 2005-9531 , 2586-7024
    Language: English
    Publisher: Kosin University College of Medicine
    Publication Date: 2017
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2017
    In:  Pain Research and Management Vol. 2017 ( 2017), p. 1-7
    In: Pain Research and Management, Hindawi Limited, Vol. 2017 ( 2017), p. 1-7
    Abstract: Background . Several studies have shown that dexmedetomidine (DXM), a selective α 2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied. Materials and Methods . Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM). The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20  μ g·kg −1 (groups 3A, 3B, and 3C, resp.). The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks. Results . There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury. However, SFI differences were statistically significant at 6 weeks postinjury in group 3. The gross findings with H & E staining showed that the number of axons was higher in group 3 than in group 2. There was no histological difference according to the DXM concentration. Conclusion . The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves.
    Type of Medium: Online Resource
    ISSN: 1203-6765 , 1918-1523
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2048409-4
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  • 7
    Online Resource
    Online Resource
    The Institute of Medical Science, Chosun University ; 2018
    In:  Medical Biological Science and Engineering Vol. 1, No. 2 ( 2018-07-31), p. 61-64
    In: Medical Biological Science and Engineering, The Institute of Medical Science, Chosun University, Vol. 1, No. 2 ( 2018-07-31), p. 61-64
    Type of Medium: Online Resource
    ISSN: 2586-5188 , 2586-5196
    Language: English
    Publisher: The Institute of Medical Science, Chosun University
    Publication Date: 2018
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