In:
ECS Meeting Abstracts, The Electrochemical Society, Vol. MA2016-02, No. 50 ( 2016-09-01), p. 3750-3750
Abstract:
Plasma is high energy electromagnetic radiation. Recently a non-thermal plasma treatment has been employed in emerging new biomedical applications, including bacterial decontamination and chronic wound treatment. Such antimicrobial and healing efficacies may be related to the formation of reactive oxygen and nitrogen species (ROS and RNS; e.g., OH· – , O 2 · – , NO, ONOO· – , and H 2 O 2 ) by plasma treatment. Among several reactive species, nitric oxide (NO) has been extensively studied due to its phagocytic and antithrombotic activities, and angiogenic property. In addition, hydrogen peroxide (H 2 O 2 ), another major species produced by plasma treatment is implicated as the main transmitter of a redox signal in several biological processes. To elucidate bioplasma science, it is essential to real-time, in-situ determine NO and H 2 O 2 produced during plasma treatment and their generation kinetics. Herein we report on a microsensor array to selectively detect NO and H 2 O 2 generated by non-thermal plasma irradiation, respectively. Two working electrodes (Pt for NO sensing and Pt/aniline derivative for H 2 O 2 sensing, respectively) are modified with a perfluorinated xerogel as a permselective membrane to improve sensor’s selectivities over readily oxidizable interfering species and other ROS and RNS. In addition, the effect of the plasma gas composition (O 2 /N 2 ratio) on NO/H 2 O 2 production ratio will be studied. Finally the microarray sensor will be employed to determine NO and H 2 O 2 generation during plasma irradiation in biological milieu in vivo or ex vivo .
Type of Medium:
Online Resource
ISSN:
2151-2043
DOI:
10.1149/MA2016-02/50/3750
Language:
Unknown
Publisher:
The Electrochemical Society
Publication Date:
2016
detail.hit.zdb_id:
2438749-6
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