In:
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 313, No. 6 ( 2017-12-01), p. E748-E756
Abstract:
A hypothesis that postchallenge hyperglycemia in subjects with low body weight (BW) may be due, in part, to small glucose volume (G V ) was tested. We studied 11,411 nondiabetic subjects with a mean BW of 63.3 kg; 5,282 of them were followed for a mean of 5.3 yr. In another group of 1,537 nondiabetic subjects, insulin sensitivity, secretion, and a product of the two (index of whole body insulin action) were determined. Corrected 2 h-plasma glucose (2hPG corr ) during a 75-g oral glucose tolerance test in subjects with BW ≤ 59 kg was calculated as 2hPG corr = δPG 2h · ECW/[16.1 (males) or 15.3 (females)] + fasting PG (FPG), where δPG 2h is plasma glucose increment in 2 h; ECW is extracellular water (surrogate of G V ); FPG is fasting plasma glucose; and 16.1 and 15.3 are ECW of men and women, respectively, with BW = 59 kg. Multivariate analyses for BW with adjustment for age, sex, and percent body fat were undertaken. BW was, across its entire range, positively correlated with FPG ( P 〈 0.01). Whereas BW was correlated with 2hPG and δPG in a skewed J-shape, with inflections at around 60 kg ( P for nonlinearity 〈 0.01 for each). Nonetheless, in those with BW ≤ 59 kg, insulin sensitivity, secretion, and action were unattenuated, and incident diabetes was less compared with heavier counterparts. BW was linearly correlated with 2hPG corr , i.e., the J-shape correlation was mitigated by the correction. In conclusion, postchallenge hyperglycemia in low BW subjects is in part due to small G V rather than impaired glucose metabolism.
Type of Medium:
Online Resource
ISSN:
0193-1849
,
1522-1555
DOI:
10.1152/ajpendo.00203.2017
Language:
English
Publisher:
American Physiological Society
Publication Date:
2017
detail.hit.zdb_id:
1477331-4
SSG:
12
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