In:
Current Topics in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 23, No. 11 ( 2023-04), p. 1004-1041
Abstract:
Neglected tropical diseases (NTDs) affect mainly poor and marginalized populations of tropical and subtropical areas in 150 countries. Many of the chemical processes involved in the syn-thesis of active pharmaceutical ingredients (APIs) are highly polluting and inefficient, both in terms of materials and energy-consuming. In this review, we present the green protocols developed in the last 10 years to access new small molecules with potential applications in the treatment of leishma-nia, tuberculosis, malaria, and Chagas disease. The use of alternative and efficient energy sources, like microwaves and ultrasound, as well as reactions using green solvents and solvent-free proto-cols, are discussed in this review.
Type of Medium:
Online Resource
ISSN:
1568-0266
DOI:
10.2174/1568026623666230526161055
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
SSG:
15,3
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