In:
Frontiers in Microbiology, Frontiers Media SA, Vol. 15 ( 2024-6-18)
Abstract:
Previous research has hinted at a crucial link between gut microbiota and arterial embolism and thrombosis, yet the causal relationship remains enigmatic. To gain a deeper understanding, we aimed to comprehensively explore the causal relationship and elucidate the impact of the gut microbiota on the risk through a two-sample Mendelian randomization (MR) study. Methods Genetic instrumental variables for gut microbiota were identified from a genome-wide association study (GWAS) of 18,340 participants. Summary statistics for IBS were drawn from a GWAS including 1,076 cases and 381,997 controls. We used the inverse-variance weighted (IVW) method as the primary analysis. To test the robustness of our results, we further performed the weighted median method, MR-Egger regression, and MR pleiotropy residual sum and outlier test. Results We identified three bacterial traits that were associated with the risk of arterial embolism and thrombosis: odds ratio (OR): 1.58, 95% confidence interval (CI): 1.08–2.31, p = 0.017 for genus Catenibacterium ; OR: 0.64, 95% CI: 0.42–0.96, p = 0.031 for genus Dialister ; and OR: 2.08, 95% CI: 1.25–3.47, p = 0.005 for genus Odoribacter . The results of sensitivity analyses for these bacterial traits were consistent ( P & lt;0.05). Conclusion Our systematic analyses provided evidence to support a potential causal relationship between several gut microbiota taxa and the risk of arterial embolism and thrombosis. More studies are required to show how the gut microbiota affects the development of arterial embolism and thrombosis.
Type of Medium:
Online Resource
ISSN:
1664-302X
DOI:
10.3389/fmicb.2024.1396699
DOI:
10.3389/fmicb.2024.1396699.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2024
detail.hit.zdb_id:
2587354-4
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