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  • 1
    Online Resource
    Online Resource
    Prognostic nomogram for percutaneous balloon compression in the treatment of trigeminal neuralgia
    Springer Science and Business Media LLC ; 2022
    In:  Neurosurgical Review Vol. 45, No. 1 ( 2022-02), p. 561-569
    Details
    In: Neurosurgical Review, Springer Science and Business Media LLC, Vol. 45, No. 1 ( 2022-02), p. 561-569
    Type of Medium: Online Resource
    ISSN: 0344-5607 , 1437-2320
    URL: Article
    DOI: 10.1007/s10143-021-01514-4
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1474861-7
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  • 2
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    Online Resource
    Effect of venovenous extracorporeal membrane oxygenation on the heart in a healthy piglet model
    Springer Science and Business Media LLC ; 2013
    In:  Journal of Cardiothoracic Surgery Vol. 8, No. 1 ( 2013-12)
    Details
    In: Journal of Cardiothoracic Surgery, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2013-12)
    Abstract: Cardiac function is important for patients treated by venovenous extracorporeal membrane oxygenation (VV ECMO), but data about the effect of VV ECMO on the heart in nonneonates is absent. We studied the effect of VV ECMO on cardiac performance, cardiomyocyte and mitochondria in an animal model. Methods Twelve farm piglets were randomly assigned into two groups: control group and ECMO group. In the ECMO group, ECMO cannulaes were placed and ECMO was instituted. Hemodynamics was recorded at baseline, 1 hour after induction, and every 4 hours thereafter, to assess the cardiac performance. All animals were monitored for 24 hours and were euthanized and myocardium was harvested. Myocardial histology, ultrastructure of cardiomyocyte and mitochondria were observed, and activities of mitochondrial complexes I-V were measured, to assess the effect to cardiomyocyte and mitochondria. Results Hemodynamics were stable in each group of animals throughout the experiment. Interstitial edema, disorderd and dissolved of focal myofilament, morphological deformations of mitochondria were observed in the ECMO group. The activities of mitochondrial complexes were decreased in the ECMO group, and complex I and IV reached significance. Conclusions VV ECMO therapy is associated with changes of ultrastructure and function of cardiomyocyte and mitochondria, inducing myocardium injury. However, the injury was mild and had no effect on the cardiac performance for healthy piglets.
    Type of Medium: Online Resource
    ISSN: 1749-8090
    URL: Article
    DOI: 10.1186/1749-8090-8-163
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 2227224-0
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  • 3
    Online Resource
    Online Resource
    Papillary meningioma: an aggressive variant meningioma with clinical features and treatment: a retrospective study of 10 cases
    Informa UK Limited ; 2016
    In:  International Journal of Neuroscience Vol. 126, No. 10 ( 2016-10-02), p. 878-887
    Details
    In: International Journal of Neuroscience, Informa UK Limited, Vol. 126, No. 10 ( 2016-10-02), p. 878-887
    Type of Medium: Online Resource
    ISSN: 0020-7454 , 1543-5245
    URL: Article
    DOI: 10.3109/00207454.2015.1077833
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2041856-5
    SSG: 12
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  • 4
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    Online Resource
    GPBAR1 Promotes Proliferation of Serous Ovarian Cancer by Inducing Smad4 Ubiquitination
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Applied Immunohistochemistry & Molecular Morphology Vol. 29, No. 7 ( 2021-08), p. 519-526
    Details
    In: Applied Immunohistochemistry & Molecular Morphology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 7 ( 2021-08), p. 519-526
    Abstract: Ovarian cancer (OC) is the most lethal malignancy of all female cancers and lacks an effective prognostic biomarker. Serous ovarian cancer (SOC) is the most common OC histologic type. The expression and function of bile acid receptor, G-protein-coupled bile acid receptor-1 (GPBAR1), in tumor progression remains controversial, and its clinical significance in SOC is unclear. Materials and Methods: In our study, we detected the expression of GPBAR1 in SOCs and normal ovarian tissues with quantitative real-time polymerase chain reaction and immunohistochemistry to detect its expression pattern. Moreover, the prognostic significance of GPBAR1 was investigated with univariate and multivariate analyses. The function of GPBAR1 in regulating SOC proliferation was studied and the underlying mechanism was investigated with experiments in vitro. Results: GPBAR1 was overexpressed in SOCs compared with the normal ovarian tissues. In the 166 SOCs, subsets with low and high GPBAR1 accounted for 57.23% and 42.77%, respectively. Moreover, our results suggested that GPBAR1 expression was significantly associated with poor prognosis and can be considered as an independent prognostic biomarker. With experiments in vitro, we suggested that GPBAR1 promoted SOC proliferation by increasing Smad4 ubiquitination, which required the involvement of GPBAR1-induced ERK phosphorylation. Conclusions: GPBAR1 was overexpressed in SOC and predicted the poor prognosis of SOC. We showed that GPBAR1 promoted SOC proliferation by activating ERK and ubiquitining Smad4. Our results suggested that GPBAR1 was a supplement to better classify SOC on the basis of the molecular profile and that GPBAR1 may be a potential drug target of SOC.
    Type of Medium: Online Resource
    ISSN: 1541-2016
    URL: Article
    DOI: 10.1097/PAI.0000000000000917
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2052398-1
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  • 5
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    Treatment of Trigeminal Neuralgia with “Microvascular Decompression Plus” Technique
    Georg Thieme Verlag KG ; 2021
    In:  Journal of Neurological Surgery Part B: Skull Base Vol. 82, No. S 03 ( 2021-07), p. e295-e299
    Details
    In: Journal of Neurological Surgery Part B: Skull Base, Georg Thieme Verlag KG, Vol. 82, No. S 03 ( 2021-07), p. e295-e299
    Abstract: Objective Although microvascular decompression (MVD) has been widely accepted as an effective treatment of trigeminal neuralgia (TN), some patients have not been cured. To improve the postoperative outcome, the surgical procedure should be further refined. Design This is a retrospective study. Setting Present study conducted at a cranial nerve disorder center. Participants Clinical data were collected from patients with TN who had undergone surgery in our center, including 685 who had undergone traditional MVD and 576 who had undergone the “MVD plus” procedure, in which any vessel attached to the trigeminal nerve was freed away (“nerve-combing”), which was followed by intraoperative neurolysis. Main Outcome Measures Postoperative outcomes and complications in the two groups were compared. Results Among patients who underwent traditional MVD, the rates of immediate relief and 1-year relief were 89.9 and 86.9%, respectively; among patients who underwent MVD plus group, these rates were 95.1 and 94.6%, respectively (p = 0.05). Patients who underwent MVD plus initially exhibited a higher rate of facial numbness (p  〈  0.05), but this finding decreased over time and reached the same level as that in the traditional MVD group within 3 months (p  〉  0.05). Conclusion Sufficient MVD with nerve-combing for the treatment of TN may produce a high rate of cure with less recurrence.
    Type of Medium: Online Resource
    ISSN: 2193-6331 , 2193-634X
    URL: Article
    DOI: 10.1055/s-0040-1710520
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 2653367-4
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  • 6
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    Estrogen Maintains Skeletal Muscle in Septic Rats Associated with Altering Hypothalamic Inflammation and Neuropeptides
    Georg Thieme Verlag KG ; 2017
    In:  Hormone and Metabolic Research Vol. 49, No. 03 ( 2017-2-13), p. 221-228
    Details
    In: Hormone and Metabolic Research, Georg Thieme Verlag KG, Vol. 49, No. 03 ( 2017-2-13), p. 221-228
    Type of Medium: Online Resource
    ISSN: 0018-5043 , 1439-4286
    URL: Article
    DOI: 10.1055/s-0043-100221
    RVK:
    XA 46918
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2017
    detail.hit.zdb_id: 2056576-8
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  • 7
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    CA 10 and CA 11 negatively regulate neuronal activity‐dependent growth of gliomas
    Wiley ; 2019
    In:  Molecular Oncology Vol. 13, No. 5 ( 2019-05), p. 1018-1032
    Details
    In: Molecular Oncology, Wiley, Vol. 13, No. 5 ( 2019-05), p. 1018-1032
    Abstract: Recent studies have revealed that neurons can promote glioma growth through activity‐dependent secretion of neurotrophins, especially neuroligin‐3. It has therefore been suggested that blocking neuron‐derived neurotrophins may serve as a therapeutic intervention for gliomas. Carbonic anhydrase‐related proteins 11 and 10 ( CA 11 and CA 10) are secreted synaptic proteins which function as neurexin ligands, and the gene‐encoding CA 11 is part of a gene signature associated with radiotherapy and prognosis in gliomas. We therefore hypothesized that CA 11/ CA 10 might participate in the neuronal activity‐dependent regulation of glioma growth. In this study, we report that CA 11 secreted by depolarized cultured neurons within conditioned medium ( CM ) inhibited the growth of glioma cell lines. CM from depolarized neurons inhibited CA 11 expression in glioma cell lines via the Akt signaling pathway. Consistently, CA 11 expression was also reduced in clinical glioma samples and negatively associated with high histological grade. Low CA 11 expression of gliomas was associated with short survival in four independent datasets [repository of brain neoplasia data ( REMBRANDT ), The Cancer Genome Atlas ( TCGA ) lower grade glioma (LGG), GSE4271 , and GSE42669 ]. CA 11 knockdown promoted cell growth, clone formation, and migration; inhibited apoptosis; and increased tumor size in xenografted nude mice. Similarly, CA 10 and CA 10 secreted by depolarized cultured neurons also inhibited the growth of glioma cell lines. Low CA 10 expression was associated with short survival in REMBRANDT , TCGA LGG , and GEO GSE4271 datasets. Our results suggest that CA 11 and CA 10 negatively regulate neuronal activity‐dependent glioma growth and inhibit glioma aggression. Thus, CA 11/ CA 10 may represent a potential therapeutic target for the treatment of gliomas.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.2019.13.issue-5
    DOI: 10.1002/1878-0261.12445
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2322586-5
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  • 8
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    The Effect of Extracorporeal Membrane Oxygenation Therapy on Systemic Oxidative Stress Injury in a Porcine Model
    Wiley ; 2014
    In:  Artificial Organs Vol. 38, No. 5 ( 2014-05), p. 426-431
    Details
    In: Artificial Organs, Wiley, Vol. 38, No. 5 ( 2014-05), p. 426-431
    Abstract: Extracorporeal membrane oxygenation ( ECMO ) therapy can result in systemic immune inflammation and trigger a hemolytic response, both of which can lead to oxidative stress injury. However, currently, there are few studies about whether ECMO can lead to oxidative stress injury. The objective of this study was to determine the effect of ECMO therapy on systemic oxidative stress. Twelve pigs were randomly divided into control and ECMO treatment groups. Blood samples were collected at −1, 0, 2, 6, 12, and 24 h during ECMO therapy in order to measure the levels of various oxidative stress markers in plasma. All animals included in the study were euthanized after 24 h of ECMO treatment. Malondialdehyde ( MDA ) was used as a marker of oxidation, and superoxide dismutase ( SOD ), glutathione ( GSH ), and total antioxidant capacity ( T ‐ AOC ) were used as indices for antioxidant activity. The plasma levels of each molecule were similar when measured at −1 and 0 h ( P   〉  0.05). In the control group, MDA , SOD , GSH , and T ‐ AOC remained relatively constant throughout the study period. However, when ECMO was administered for 2 h, plasma levels of MDA increased significantly; conversely, levels of SOD , GSH , and T ‐ AOC decreased. Maximum MDA levels and minimal SOD , GSH , and T ‐ AOC levels were observed after 6 h of ECMO treatment. MDA and SOD levels had returned to baseline at 24 h. At this time‐point, levels of MDA and T ‐ AOC in samples from the right frontal cortex and jejunum differed significantly between the control and ECMO treatment groups. These results show that early ECMO treatment can induce significant oxidative stress injury in plasma. However, in the latter stage of the treatment, the oxidative stress injury can be repaired gradually. ECMO treatment can also result in mild oxidative stress injury in the jejunum and brain tissue.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.2014.38.issue-5
    DOI: 10.1111/aor.12198
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2003825-2
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  • 9
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    Online Resource
    Intelligent Recognition Technology for the Segmentation of Traffic Indication Images Concerning Different Pavement Materials
    Hindawi Limited ; 2022
    In:  Applied Bionics and Biomechanics Vol. 2022 ( 2022-9-20), p. 1-7
    Details
    In: Applied Bionics and Biomechanics, Hindawi Limited, Vol. 2022 ( 2022-9-20), p. 1-7
    Abstract: Traffic indication is an important part of the road environment, providing information about road conditions, restrictions, prohibitions, warnings, and the current status related to the flow of the traffic and other navigational aspects. The shape, color, and pictogram of a traffic indication are encoded into the visual characteristics of traffic signs. Not paying attention to these traffic signs could lead directly or indirectly to traffic accidents. In this article, the support traffic indication vector recognition (STIVR) method is proposed to classify the best signal detection to avoid traffic congestion and accidents. The proposed STIVR recognizes the traffic indication system automatically, reduces occurrences of traffic accidents, and helps drivers move safely on different pavement materials. Besides, the adaptive median filter (AMF) algorithm is used to pre-process and protect the traffic indication images without obscuring them. Thus, it indicates the edge of the non-smoothed nasty ferment from the service. In the detection of traffic events, indication images are enhanced, pre-treated, and divided according to symbols and their characteristics such as color, shape, or both. The output becomes a segmented image, including the available space identified as a road sign. The experimental results show that the proposed method functions well; achieves a sufficiently higher process speed and better segmentation of traffic indications and more accuracy in recognition of the objects. For example, the proposed method reaches a higher sensitivity performance of 96%.
    Type of Medium: Online Resource
    ISSN: 1754-2103 , 1176-2322
    URL: Article
    DOI: 10.1155/2022/6278240
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2179924-6
    SSG: 12
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  • 10
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    Table_2.xlsx
    Frontiers Media SA ; 2020
    In:  Frontiers in Oncology Vol. 10 ( 2020-12-14)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 10 ( 2020-12-14)
    Abstract: Emerging molecular diagnostic methods are more sensitive and objective, which can overcome the intrinsic failings of morphological diagnosis. Here, a RT-PCR-based in vitro diagnostic test kit (LungMe ® ) was developed and characterized to simultaneously quantify the DNA methylation of SHOX2 and RASSF1A in FFPE tissue specimens. The clinical manifestations were evaluated in 251 FFPE samples with specificity and sensitivity of 90.4 and 89.8%, respectively. Furthermore, the quantitative analysis shows that the degree of SHOX2 methylation was correlated with the stages of lung cancer, but not in the case of RASSF1A . Our observation indicated that the DNA methylation of SHOX2 and RASSF1A may play different roles in cancer development. Comparison of the methylation levels of SHOX2 and RASSF1A between cancer and cancer-adjacent specimens (n = 30), showed they have “epigenetic field defect”. As additional clinical validation, the hypermethylation of SHOX2 and RASSF1A was detected not only in surgical operative specimens, but also in histopathological negative puncture biopsies. SHOX2 and RASSF1A methylation detection can be used to increase sensitivity and NPV, which provide us with a more accurate method of differential diagnosis and are likely to be rapidly applied in clinical examinations.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2020.565780
    DOI: 10.3389/fonc.2020.565780.s001
    DOI: 10.3389/fonc.2020.565780.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2649216-7
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