In:
Synthesis, Georg Thieme Verlag KG, Vol. 54, No. 10 ( 2022-05), p. 2340-2349
Abstract:
Suzuki–Miyaura coupling is an extremely useful way to construct Csp2–Csp2 carbon bonds. On the other hand, Csp2–Csp3 coupling reactions do not work well, and tert-alkylative Suzuki–Miyaura coupling is particularly challenging due to problematic oxidative addition and β-hydride elimination side reactions. In this short review, we will introduce recent examples of tert-alkylative Suzuki–Miyaura couplings with tert-alkyl electrophiles or -boron reagents. The review will mainly focus on catalyst and product structures and on the proposed mechanisms. 1 Introduction 2 Ni-Catalyzed tert-Alkylative Couplings 3 Pd-Catalyzed tert-Alkylative Couplings 4 Fe-Catalyzed tert-Alkylative Couplings 5 tert-Alkylative Couplings with 1-Alkenyl Borons 6 tert-Alkylative Couplings under Photoirradiation 7 Stereospecific tert-Alkylative Couplings 8 Conclusion
Type of Medium:
Online Resource
ISSN:
0039-7881
,
1437-210X
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
detail.hit.zdb_id:
204080-3
detail.hit.zdb_id:
2033062-5
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