In:
Asian Journal of Pharmaceutical and Clinical Research, Innovare Academic Sciences Pvt Ltd, Vol. 11, No. 11 ( 2018-11-07), p. 368-
Abstract:
Objective: The objective of this study was to evaluate the prophylactic effect of Kadukkai maathirai (KM) against ethanol-induced hepatotoxicity in rats.Methods: Four groups (n=6) of adult female Sprague–Dawley rats were used. Ethanol was administered in the dose of 45% v/v 15 mL/kg/body weight twice a day for 8 weeks in the study. The four groups were treated orally for 8 weeks with 2% gum acacia (control), ethanol (toxic control), ethanol + KM 72 mg/kg, and ethanol + KM 400 mg/kg, respectively. At the end of 8 weeks, blood was collected by a retro-orbital puncture for the estimation of liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT] ). The liver was dissected out for histopathology. Using one-way ANOVA and post hoc Tukey’s test, the data were analyzed.Results: There was a significant (p 〈 0.05) decrease in the serum AST and ALT level in rats treated with KM 72 mg/kg as compared to toxic control. Liver parenchyma showed near normal architecture in KM 72 mg/kg-treated group as compared to ethanol-treated group which showed extensive ballooning degeneration of hepatocytes and microvesicular steatosis.Conclusion: KM, in the dose of 72 mg/kg, which is the therapeutic dosage described in Siddha additional literature, exerted hepatoprotective effect against ethanol-induced liver damage in rats.
Type of Medium:
Online Resource
ISSN:
2455-3891
,
0974-2441
DOI:
10.22159/ajpcr.2018.v11i11.26773
Language:
Unknown
Publisher:
Innovare Academic Sciences Pvt Ltd
Publication Date:
2018
detail.hit.zdb_id:
2500247-8
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