In:
Natural Products and Bioprospecting, Springer Science and Business Media LLC, Vol. 10, No. 4 ( 2020-08), p. 243-250
Abstract:
Two new sesquiterpenoids, artemlavanins A ( 1 ) and B ( 3 ), together with fifteen known compounds ( 2 and 4−17 ) were isolated from the EtOH extract of Artemisia lavandulaefolia . The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5 , 6–8 , 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds ( 1–3 , 5–7 , 10–12 , 14 , 15 and 17 ) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with IC 50 values ranging from 35.1 to 370.3 μ M. Compounds 2 , 7 , 10–12 and 17 exhibited the stronger cytotoxicity than silybin (IC 50 , 169.6 μ M) with IC 50 values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μ M. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with IC 50 values of 10.7, 24.5 and 13.3 μ M. Graphic Abstract
Type of Medium:
Online Resource
ISSN:
2192-2195
,
2192-2209
DOI:
10.1007/s13659-020-00254-0
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2636293-4
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