In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 639 ( 2022-04-06)
Abstract:
Individuals with diabetes often suffer from chronic diabetic neuropathic pain (DNP). The mechanisms mediating the development of DNP are not completely elucidated. Now, Xie et al. reported that the orphan G protein–coupled receptor GPR177 expressed in A-fiber dorsal root ganglion (DRG) neurons is required for the development of DNP in mice. Activation of GRP177 resulted in WNT5a release and subsequent activation of the TRPV1 ion channel. Pharmacological blockade of the interaction between WNT5a and TRPV1 eliminated DNP in rodents. In subjects with DNP, WNT5A secretion in CSF was increased compared with diabetic patients without DNP, suggesting that the GPR177-WNT5A-TRPV1 pathway could be a potential target for treating DNP in diabetic individuals.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abh2557
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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