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  • 1
    Online Resource
    Online Resource
    Sarcopenia as a Determinant of the Efficacy of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: A Meta-Analysis
    Informa UK Limited ; 2023
    In:  Nutrition and Cancer Vol. 75, No. 2 ( 2023-02-07), p. 685-695
    Details
    In: Nutrition and Cancer, Informa UK Limited, Vol. 75, No. 2 ( 2023-02-07), p. 685-695
    Type of Medium: Online Resource
    ISSN: 0163-5581 , 1532-7914
    URL: Article
    DOI: 10.1080/01635581.2022.2153879
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
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  • 2
    Online Resource
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    DataSheet1.ZIP
    Frontiers Media SA ; 2021
    In:  Frontiers in Pharmacology Vol. 12 ( 2021-12-14)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-12-14)
    Abstract: Atopic dermatitis (AD) is a common chronic relapsing skin inflammation, which severely affect the quality of life of patients. Inhibiting itching and enhancing immunity to mitigate scratching are key elements in the fight against AD. Huanglian Jiedu decoction (HLJDD) has multiple pharmacological effects in the treatment of AD. However, the effective ingredients and underlying molecular mechanisms have not yet been fully explored. Thus, this study integrates chemistry, biochemistry, and metabolomics strategies to evaluate the active substance basis of HLJDD against AD. First, HLJDD was split to five fractions (CPF, 40AEF, 90AEF, PEF and WEF) and 72 chemical components were identified. NSD (Non-similarity degree) among the different fractions showed significant chemical differences ( & gt;81%). Interleukin IL-13, IL-17A, IL-3, IL-31, IL-33, IL4, IL-5, TSLP, IgE, and histamine in the serum, and IL-4Rα, JAK1, and HRH4 levels in skin, participating in inhibiting itching and regulating immunity signaling, were found to be restored to varying degrees in AD treating with HLJDD and its fractions, especially 40AEF and CPF. Untargeted metabolomics analysis demonstrated that forty metabolites were differential metabolites in plasma between the HLJDD-treated group and the AD group, involving in histidine metabolism, arginine biosynthesis, pyrimidine metabolism, and so on. Further, targeted metabolomics analysis revealed that eleven differential metabolites, associating with physiological and biochemical indices, were significant improved in the HLJDD and its fractions groups. In conclusion, HLJDD exhibited anti-AD effects by inhibiting itching and enhancing immunity, which in turn regulating the levels of relative metabolites, and CPF and 40AEF were considered the most important components of HLJDD.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2021.770524
    DOI: 10.3389/fphar.2021.770524.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Toward a New Energy Era: Self‐Driven Integrated Systems Based on Perovskite Solar Cells
    Wiley ; 2019
    In:  Solar RRL Vol. 3, No. 11 ( 2019-11)
    Details
    In: Solar RRL, Wiley, Vol. 3, No. 11 ( 2019-11)
    Abstract: Integrated smart portable devices (e.g., self‐powered devices) that utilize the environment‐friendly energy (e.g., solar energy) by means of photovoltaic technology (e.g., solar cell) are a popular concept in the current technological development trend. As a key component of integrated devices, photovoltaic devices acting as a bridge between solar energy and working devices play an important role in the whole system performance. The emergence of perovskite solar cells (PSCs) with high power conversion efficiencies (over 25%) allows for the possibility and appearance of many multifunctional self‐powered integrated devices. In this review, a systematic overview of self‐powered integrated devices based on PSCs that are reported so far is provided, including integrated energy storage devices, integrated artificial photosynthesis devices, and other self‐powered integrated devices. The key strategies for fabricating these devices and performance are also discussed to further the understanding of fundamental device physics. Finally, the current challenging issues and future perspective are provided to promote the development of self‐powered integrated devices based on PSCs in the near future.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v3.11
    DOI: 10.1002/solr.201900320
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2882014-9
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  • 4
    Online Resource
    Online Resource
    Diazoxide ameliorates severity of experimental osteoarthritis by activating autophagy via modulation of the osteoarthritis‐related biomarkers
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 11 ( 2018-11), p. 8922-8936
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 11 ( 2018-11), p. 8922-8936
    Abstract: Accumulating evidence suggests that autophagy plays a protective role in chondrocytes and prevents cartilage degeneration in osteoarthritis (OA). The objective of this study was to investigate the effect of diazoxide on chondrocyte death and cartilage degeneration and to determine whether these effects are correlated to autophagy in experimental OA. In this study, a cellular OA model was established by stimulating SW1353 cells with interleukin 1β. A rat OA model was generated by transecting the anterior cruciate ligament combined with the resection of the medial menisci, followed by treatment with diazoxide or diazoxide combination with 3‐methyladenine. The percentage of viable cells was evaluated using calcein‐acetoxymethyl/propidium iodide double staining. The messenger RNA expression levels of collagen type II alpha 1 chain (COL2A1), matrix metalloproteinase 13 (MMP‐13), TIMP metallopeptidase inhibitor 1 (TIMP‐1), and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) were determined using quantitative real‐time polymerase chain reaction. The cartilage thickness and joint space were evaluated using ultrasound. SW1353 cell degeneration and autophagosomes were observed using transmission electron microscopy. The expression levels of microtubule‐associated protein 1 light chain 3 (LC3), beclin‐1, P62, COL2A1, and MMP‐13 were evaluated using immunofluorescence staining and Western blot analysis. Diazoxide significantly attenuated articular cartilage degeneration and SW1353 cell death in experimental OA. The restoration of autophagy was observed in the diazoxide‐treated group. The beneficial effects of diazoxide were markedly blocked by 3‐methyladenine. Diazoxide treatment also modulated the expression levels of OA‐related biomarkers. These results demonstrated that diazoxide exerted a chondroprotective effect and attenuated cartilage degeneration by restoring autophagy via modulation of OA‐related biomarkers in experimental OA. Diazoxide treatment might be a promising therapeutic approach to prevent the development of OA.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.11
    DOI: 10.1002/jcb.27145
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Distribution and molecular characterization of Citrus leaf blotch virus from Actinidia in Shaanxi province, China
    Springer Science and Business Media LLC ; 2019
    In:  European Journal of Plant Pathology Vol. 154, No. 3 ( 2019-7), p. 855-862
    Details
    In: European Journal of Plant Pathology, Springer Science and Business Media LLC, Vol. 154, No. 3 ( 2019-7), p. 855-862
    Type of Medium: Online Resource
    ISSN: 0929-1873 , 1573-8469
    URL: Article
    DOI: 10.1007/s10658-019-01677-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 1477679-0
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Table2.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-9-6)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-9-6)
    Abstract: Ulcerative colitis (UC), characterized by syndromes including abdominal pain, bloody stool, diarrhea, weight loss, and repeated relapse, is a non-specific inflammatory intestinal disease. In recent years, with the changing dietary habits in China, the incidence of UC has shown an upward trend. UC belongs to the category of recorded as “diarrhea,” “chronic dysentery,” and “hematochezia” in traditional Chinese medicine (TCM), and Shenling BaiZhu powder (SLBZP) is one of the most effective and commonly used prescriptions. In this review, we aim to systematically summarize the clinical application and pharmacological mechanism of SLBZP in the treatment of UC to provide a theoretical basis for its clinical use and experimental evaluation of SLBZP. Our results showed that both SLBZP and SLBZP in combination with chemical drugs, have a significant therapeutic effect against UC with few adverse reactions. Furthermore, combined therapy was better than western medicine. Further, pathophysiological studies indicated that SLBZP has anti-inflammatory, immunomodulatory, antioxidant effects, regulation relative cell signal transduction and regulation of gut microbiota. Although evidence suggests superior therapeutic efficacy of SLBZP for treating UC and the relative mechanism has been studied extensively, various shortcomings limit the existing research on the topic. There is a lack of UC animal models, especially UC with TCM syndromes, with no uniform standard and certain differences between the animal model and clinical syndrome. The dosage, dosage form, and therapeutic time of SLBZP are inconsistent and lack pharmacological verification, and clinical trial data are not detailed or sufficiently rigorous. In addition, SLSZP is composed of multiple Chinese drugs that contain massive numbers of ingredients and which or several components contribute to therapeutic effects. How they work synergistically together remains unknown. Therefore, on the one hand, large sample prospective cohort studies to clarify the clinical efficacy and safety of SLBZP in the treatment of UC are needed. In contrast, researchers should strengthen the study of the molecular biological mechanism of active ingredients and its synergistic actions, clarifying the mechanism of SLBZP in treating UC by multi-component, multi-target, and multi-pathway.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2022.978558
    DOI: 10.3389/fphar.2022.978558.s001
    DOI: 10.3389/fphar.2022.978558.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Growth and reproduction of the green macroalga Ulva prolifera
    Acta Ecologica Sinica ; 2012
    In:  Acta Ecologica Sinica Vol. 32, No. 2 ( 2012), p. 421-430
    Details
    In: Acta Ecologica Sinica, Acta Ecologica Sinica, Vol. 32, No. 2 ( 2012), p. 421-430
    Type of Medium: Online Resource
    ISSN: 1000-0933
    Uniform Title: 大型绿藻浒苔藻段及组织块的生长和发育特征
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.5846/stxb/2012/32/2
    DOI: 10.5846/stxb
    DOI: 10.5846/stxb201012081750
    Language: English , Chinese
    Publisher: Acta Ecologica Sinica
    Publication Date: 2012
    detail.hit.zdb_id: 2467991-4
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  • 8
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    Online Resource
    Barley yellow dwarf virus-GAV-derived vsiRNAs are involved in the production of wheat leaf yellowing symptoms by targeting chlorophyll synthase
    Springer Science and Business Media LLC ; 2020
    In:  Virology Journal Vol. 17, No. 1 ( 2020-12)
    Details
    In: Virology Journal, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2020-12)
    Abstract: Wheat yellow dwarf virus disease is infected by barley yellow dwarf virus (BYDV), which causes leaf yellowing and dwarfing symptoms in wheat, thereby posing a serious threat to China's food production. The infection of plant viruses can produce large numbers of vsiRNAs, which can target host transcripts and cause symptom development. However, few studies have been conducted to explore the role played by vsiRNAs in the interaction between BYDV-GAV and host wheat plants. Methods In this study, small RNA sequencing was conducted to profile vsiRNAs in BYDV-GAV-infected wheat plants. The putative targets of vsiRNAs were predicted by the bioinformatics software psRNATarget. RT-qPCR and VIGS were employed to identify the function of selected target transcripts. To confirm the interaction between vsiRNA and the target, 5′ RACE was performed to analyze the specific cleavage sites. Results From the sequencing data, we obtained a total of 11,384 detected vsiRNAs. The length distribution of these vsiRNAs was mostly 21 and 22 nt, and an A/U bias was observed at the 5′ terminus. We also observed that the production region of vsiRNAs had no strand polarity. The vsiRNAs were predicted to target 23,719 wheat transcripts. GO and KEGG enrichment analysis demonstrated that these targets were mostly involved in cell components, catalytic activity and plant-pathogen interactions. The results of RT-qPCR analysis showed that most chloroplast-related genes were downregulated in BYDV-GAV-infected wheat plants. Silencing of a chlorophyll synthase gene caused leaf yellowing that was similar to the symptoms exhibited by BYDV-GAV-inoculated wheat plants. A vsiRNA from an overlapping region of BYDV-GAV MP and CP was observed to target chlorophyll synthase for gene silencing. Next, 5′ RACE validated that vsiRNA8856 could cleave the chlorophyll synthase transcript in a sequence-specific manner. Conclusions This report is the first to demonstrate that BYDV-GAV-derived vsiRNAs can target wheat transcripts for symptom development, and the results of this study help to elucidate the molecular mechanisms underlying leaf yellowing after viral infection.
    Type of Medium: Online Resource
    ISSN: 1743-422X
    URL: Article
    DOI: 10.1186/s12985-020-01434-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2160640-7
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  • 9
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    Online Resource
    The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors
    Elsevier BV ; 2023
    In:  Cytokine & Growth Factor Reviews ( 2023-7)
    Details
    In: Cytokine & Growth Factor Reviews, Elsevier BV, ( 2023-7)
    Type of Medium: Online Resource
    ISSN: 1359-6101
    URL: Article
    DOI: 10.1016/j.cytogfr.2023.07.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2025966-9
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  • 10
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    Ultrasoft bioadhesive hydrogel as a versatile platform for the delivery of basic fibroblast growth factor to repair traumatic brain injury
    Elsevier BV ; 2024
    In:  Chemical Engineering Journal Vol. 483 ( 2024-03), p. 149017-
    Details
    In: Chemical Engineering Journal, Elsevier BV, Vol. 483 ( 2024-03), p. 149017-
    Type of Medium: Online Resource
    ISSN: 1385-8947
    URL: Article
    DOI: 10.1016/j.cej.2024.149017
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 241367-X
    detail.hit.zdb_id: 2012137-4
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