In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 31, No. 15_suppl ( 2013-05-20), p. 10022-10022
Abstract:
10022 Background: The extent to which adult survivors of childhood ALL may have impaired fitness has not been well documented. This study compared clinically assessed fitness between childhood ALL survivors and matched controls, and examined risk factors for impaired fitness among survivors. Methods: 365 survivors of childhood ALL diagnosed from 1980-2002, treated at St. Jude Children’s Research Hospital (SJCRH), 10+ years from diagnosis, and 18+ years old completed questionnaires, fitness testing and physical activity assessment (accelerometry). 365 friends/relatives of current SJCRH patients, frequency matched on age, race and sex, were recruited as controls. Data from fitness measures were combined into a composite (SJFIT) using factor analysis. Individual measures and SJFIT scores were compared between survivors and controls with two sample t-tests. Among survivors, associations between demographic, lifestyle, treatment variables and poor fitness, i.e. scoring in the lowest 10th percentile of controls on the SJFIT, were evaluated with logistic regression. Results: Survivors were 52% male (mean age 28±7 years, mean diagnosis age 6±5 years, mean survival 21±5 years), and scored lower than controls on individual fitness measures (Table) and the SJFIT composite. Female sex (OR 9.4, 95%CI 3.4-26.1) and fewer daily minutes of moderate and vigorous physical activity (OR 0.95, 95% CI 0.92-0.99) were associated with poor fitness after adjusting for diagnosis age, current age, cranial radiation, body fat and smoking. Conclusions: Childhood ALL survivors, particularly females, have fitness impairments when compared to matched controls. Poor fitness is associated with physical activity levels. Interventions to address impairments need to be tested and implemented. [Table: see text]
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2013.31.15_suppl.10022
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2013
detail.hit.zdb_id:
2005181-5
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