In:
Clinical Transplantation, Wiley, Vol. 28, No. 8 ( 2014-08), p. 889-896
Kurzfassung:
Endothelial dysfunction may explain increased cardiovascular risk in patients with chronic kidney disease ( CKD ). Methods Brachial artery was imaged during reactive hyperemia (endothelium‐dependent, flow‐mediated dilatation, FMD ) and during glyceryl trinitrate‐mediated dilatation (nitroglycerine‐mediated dilatation, NMD , endothelium‐independent) in 108 patients with CKD and three months following renal transplantation ( RT ) in 60 of them. Results Patients with CKD had significantly lower FMD vs. controls (9.1% vs. 18.3%, p 〈 0.001) while NMD was comparable (19.8% vs. 21.8%, p = ns). Impaired FMD ( 〈 4.5%) was observed in 26.8% patients with CKD and was more common in those on hemodialysis ( HD ; 28.4% vs. 15.4%) vs. those not on dialysis. FMD for patients with glomerular filtration rate ( GFR ) 15–60 vs. 〈 15 mL/min/1.73 m 2 was 12.9% and 8.8% (p = 0.05; respectively −29% and −52% lower vs. controls), indicating reduced FMD with increasing CKD severity. There was +72% increase in FMD following RT (9.1 to 15.7%, p 〈 0.001) while mean NMD was unchanged. Following RT , only 3.3% had impaired FMD . Conclusions Patients with CKD have endothelial dysfunction as evidenced by reduced FMD . Decreased FMD indicating worsening endothelial function was noted with increasing severity of CKD . Within three months of RT , there was significant improvement in FMD , while NMD values did not change.
Materialart:
Online-Ressource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2014.28.issue-8
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2739458-X
ZDB Id:
2004801-4
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