In:
ChemistrySelect, Wiley, Vol. 7, No. 48 ( 2022-12-27)
Abstract:
A series of dicationic N, N’ ‐disubstituted benzimidazolium salts with Br − and PF 6 − as the counter anions were synthesized in 75–98 % yields. The single crystal X‐ray diffraction studies of one of the benzimidazolium salts confirmed the structure of these dicationic compounds. These salts exhibited a selective “turn‐off” fluorescence response toward Fe 3+ ions in aqueous solution over the other competitive metal ions such as Ag + , Al 3+ , Ba 2+ , Ca 2+ , Co 2+ , Cr 3+ , Cu 2+ , Fe 2+ , K + , Mg 2+ , Na + , Ni 2+ , Pb 2+ , and Zn 2+ . Upon addition of 5 equivalents Fe 3+ ions, emission intensity was quenched by 94–99 % in pure aqueous media. Detection limits for all probes with Fe 3+ ions were found in micromolar range. Further, drug combination analysis was conducted by evaluating the combinatorial treatment effects of two benzimidazolium salts with doxorubicin on breast cancer cells using the Chou‐Talalay method and the Highest Single Agent (HSA) model, and it was found that these compounds showed synergism with doxorubicin. Further, molecular docking studies revealed the best docking score (−6.11) for one of the benzimidazolium salts, and explained its binding affinity with checkpoint kinase 2 (chk2) protein.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.202203239
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2844262-3
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