In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-9), p. e0282271-
Abstract:
Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals. Methods Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates. Findings The asthma PRS was associated with severe COVID-19 category (odds ratio [ OR ] = 1.61, 95% confidence interval: 1.17–2.21) and more severe COVID-19 symptomatology ( β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS ( OR = 1.97, [1.26–3.07]) and the PRS for COVID-19 hospitalization ( OR = 1.35, [1.01–1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity. Conclusion Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282271
DOI:
10.1371/journal.pone.0282271.t001
DOI:
10.1371/journal.pone.0282271.t002
DOI:
10.1371/journal.pone.0282271.t003
DOI:
10.1371/journal.pone.0282271.t004
DOI:
10.1371/journal.pone.0282271.s001
DOI:
10.1371/journal.pone.0282271.s002
DOI:
10.1371/journal.pone.0282271.s003
DOI:
10.1371/journal.pone.0282271.s004
DOI:
10.1371/journal.pone.0282271.s005
DOI:
10.1371/journal.pone.0282271.s006
DOI:
10.1371/journal.pone.0282271.s007
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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