In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-03-18)
Abstract:
The neocortex is functionally organized into layers. Layer four receives the densest bottom up sensory inputs, while layers 2/3 and 5 receive top down inputs that may convey predictive information. A subset of cortical somatostatin (SST) neurons, the Martinotti cells, gate top down input by inhibiting the apical dendrites of pyramidal cells in layers 2/3 and 5, but it is unknown whether an analogous inhibitory mechanism controls activity in layer 4. Using high precision circuit mapping, in vivo optogenetic perturbations, and single cell transcriptional profiling, we reveal complementary circuits in the mouse barrel cortex involving genetically distinct SST subtypes that specifically and reciprocally interconnect with excitatory cells in different layers: Martinotti cells connect with layers 2/3 and 5, whereas non-Martinotti cells connect with layer 4. By enforcing layer-specific inhibition, these parallel SST subnetworks could independently regulate the balance between bottom up and top down input.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.43696.001
DOI:
10.7554/eLife.43696.002
DOI:
10.7554/eLife.43696.003
DOI:
10.7554/eLife.43696.004
DOI:
10.7554/eLife.43696.005
DOI:
10.7554/eLife.43696.006
DOI:
10.7554/eLife.43696.007
DOI:
10.7554/eLife.43696.008
DOI:
10.7554/eLife.43696.009
DOI:
10.7554/eLife.43696.010
DOI:
10.7554/eLife.43696.011
DOI:
10.7554/eLife.43696.012
DOI:
10.7554/eLife.43696.013
DOI:
10.7554/eLife.43696.014
DOI:
10.7554/eLife.43696.015
DOI:
10.7554/eLife.43696.016
DOI:
10.7554/eLife.43696.017
DOI:
10.7554/eLife.43696.018
DOI:
10.7554/eLife.43696.019
DOI:
10.7554/eLife.43696.020
DOI:
10.7554/eLife.43696.021
DOI:
10.7554/eLife.43696.022
DOI:
10.7554/eLife.43696.023
DOI:
10.7554/eLife.43696.024
DOI:
10.7554/eLife.43696.025
DOI:
10.7554/eLife.43696.026
DOI:
10.7554/eLife.43696.034
DOI:
10.7554/eLife.43696.035
DOI:
10.7554/eLife.43696.028
DOI:
10.7554/eLife.43696.029
DOI:
10.7554/eLife.43696.030
DOI:
10.7554/eLife.43696.031
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2019
detail.hit.zdb_id:
2687154-3
Permalink