In:
Journal of Computer Assisted Tomography, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 6 ( 2019-11), p. 857-862
Abstract:
The objective of this study is to compare the value of monoexponential and biexponential approach to the diffusion-weighted magnetic resonance imaging signal in the prediction of the liver fibrosis. Methods Forty patients with hepatitis C were included. Quantification of the apparent diffusion coefficient (ADC) and pure molecular diffusion ( D ), pseudodiffusion ( D *), and perfusion fraction ( f ) was performed using 9 b values ( b = 0, 20, 50, 100, 200, 400, 600, 800, 1000 s/mm 2 ). Results Significant fibrosis was found in 14 subjects. Monoexponentally derived ADC parameters were significantly correlated. Apparent diffusion coefficient calculated from all b values and ADC based on high b values were significantly related to the fibrosis grade ( P 〈 0.02), and none of intravoxel incoherent motion parameters presented such an association. Apparent diffusion coefficient based on high b values was the best predictor of significant fibrosis with area under the curve of 0.81, sensitivity of 0.57, and specificity of 0.92. Conclusion Intravoxel incoherent motion parameters did not allow for prediction of the liver fibrosis. Apparent diffusion coefficient calculated based on high b values presents considerable specificity in predicting significant fibrosis.
Type of Medium:
Online Resource
ISSN:
1532-3145
,
0363-8715
DOI:
10.1097/RCT.0000000000000937
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
detail.hit.zdb_id:
2039772-0
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