In:
Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
Abstract:
This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (albuminuria ≥ 30 mg/g and/or GFR 〈 60 mL/min/1.73 m 2 ), n = 65 ; and without nephropathy (albuminuria 〈 30 mg/g and GFR ≥ 60 mL/min/1.73 m 2 ), n = 60 . INF- γ , IL-6, IL-10, and TNF- α plasma levels were determined by flow cytometry. VWF, ADAMTS13 antigen, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay and ADAMTS13 activity was assessed by fluorescence resonance energy transfer assay. Elevated levels of INF- γ , VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy ( P = 0.001 , P 〈 0.001 , P 〈 0.001 , P 〈 0.001 , and P 〈 0.001 , resp.). Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist). INF- γ , TNF- α , and IL-10 significantly correlated with haemostatic biomarkers. Inflammatory and hypercoagulability status are associated with nephropathy in type 1 diabetes mellitus and an interrelationship between them may play an important role in pathogenesis of diabetic nephropathy.
Type of Medium:
Online Resource
ISSN:
2314-6745
,
2314-6753
DOI:
10.1155/2016/2315260
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2711897-6
Permalink