In:
Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-12-19)
Abstract:
In this study, we investigate the utility of geometric orifice area (GOA) on cardiac computed tomography (CT) and differences from effective orifice area (EOA) on Doppler echocardiography in patients with bicuspid aortic stenosis (AS). Methods A total of 163 patients (age 64 ± 10 years, 56.4% men) with symptomatic bicuspid AS who were referred for surgery and underwent both cardiac CT and echocardiography within 3 months were studied. To calculate the aortic valve area, GOA CT was measured by multiplanar CT planimetry, and EOA Echo was calculated by the continuity equation with Doppler echocardiography. The relationships between GOA CT and EOA Echo and patient symptom scale, biomarkers, and left ventricular (LV) functional variables were analyzed. Results There was a significant but modest correlation between EOA Echo and GOA CT ( r = 0.604, p & lt; 0.001). Both EOA Echo and GOA CT revealed significant correlations with mean pressure gradient and peak transaortic velocity, and the coefficients were higher in EOA Echo than in GOA CT . EOA Echo of 1.05 cm 2 and GOA CT of 1.25 cm 2 corresponds to hemodynamic cutoff values for diagnosing severe AS. EOA Echo was well correlated with the patient symptom scale and log NT-pro BNP, but GOA CT was not. In addition, EOA Echo had a higher correlation coefficient with estimated LV filling pressure and LV global longitudinal strain than GOA CT . Conclusion GOA CT can be used to evaluate the severity of bicuspid AS. The threshold for GOA CT for diagnosing severe AS should be higher than that for EOA Echo . However, EOA Echo is still the method of choice because EOA Echo showed better correlations with clinical and functional variables than GOA CT .
Type of Medium:
Online Resource
ISSN:
2297-055X
DOI:
10.3389/fcvm.2022.1035244
DOI:
10.3389/fcvm.2022.1035244.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2781496-8
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