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  • 1
    In: Global Change Biology, Wiley, Vol. 28, No. 9 ( 2022-05), p. 3110-3144
    Abstract: Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1‐km 2 resolution for 0–5 and 5–15 cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1‐km 2 pixels (summarized from 8519 unique temperature sensors) across all the world's major terrestrial biomes, and coarse‐grained air temperature estimates from ERA5‐Land (an atmospheric reanalysis by the European Centre for Medium‐Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10°C (mean = 3.0 ± 2.1°C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6 ± 2.3°C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (−0.7 ± 2.3°C). The observed substantial and biome‐specific offsets emphasize that the projected impacts of climate and climate change on near‐surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil‐related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological applications.
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020313-5
    SSG: 12
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  • 2
    In: Neurobiology of Disease, Elsevier BV, Vol. 62 ( 2014-02), p. 193-207
    Type of Medium: Online Resource
    ISSN: 0969-9961
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1471408-5
    SSG: 12
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  • 3
    In: European Journal of Neuroscience, Wiley, Vol. 27, No. 4 ( 2008-02), p. 947-957
    Abstract: Alpha‐synuclein is intimately involved in the pathogenesis of Parkinson's disease, and has been implicated in the regulation of synthesis, release and reuptake of dopamine (DA). However, mice lacking members of the synuclein family have been reported to display no overt behavioural phenotype. This may be a result of compensatory upregulation of other synucleins during development. Here we report on behaviour and DA synapse function of alpha‐synuclein null, gamma‐synuclein null, and alpha‐gamma‐synuclein double‐null knockout mice. Double‐null mice were hyperactive in a novel environment and alternated at a lower rate in a T‐maze spontaneous alternation task, a phenotype reminiscent of mice expressing reduced levels of the DA transporter. To investigate a possible hyperdopaminergic phenotype in alpha‐gamma‐synuclein double‐null mice, we used fast‐scan cyclic voltammetry at carbon‐fibre microelectrodes to assess DA release and reuptake in striatal slices from wild‐type, alpha‐null, gamma‐null and double‐null mice in real time. Double‐null mice were found to have a twofold increase in the extracellular concentration of DA detected after discrete electrical stimuli in the striatum. By measuring the rate of reuptake of DA and tissue DA content in these animals, we showed that the observed increase in size of striatal DA transients was not attributable to a decrease in reuptake of DA via the DA transporter, and can not be attributed to an increase in tissue DA levels in the striatum. Rather, we propose that loss of both alpha‐ and gamma‐synuclein causes an increase in release probability from dopaminergic synapses.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    American Animal Hospital Association ; 2003
    In:  Journal of the American Animal Hospital Association Vol. 39, No. 4 ( 2003-07-01), p. 403-405
    In: Journal of the American Animal Hospital Association, American Animal Hospital Association, Vol. 39, No. 4 ( 2003-07-01), p. 403-405
    Abstract: A 10-year-old, spayed female Dalmatian was diagnosed with granulomatous urethritis causing urethral obstruction. Due to the extensive involvement of the urethra, a urethrostomy was not possible. A commercially available, silicone, low-profile gastrostomy tube was placed as a prepubic cystostomy tube to achieve urinary diversion. This tube is easy to use, has a one-way valve, and lies flush with the skin margin, thereby decreasing the likelihood of inadvertent removal. This tube should be considered to achieve long-term urinary diversion when urethral involvement is extensive.
    Type of Medium: Online Resource
    ISSN: 0587-2871 , 1547-3317
    Language: English
    Publisher: American Animal Hospital Association
    Publication Date: 2003
    SSG: 22
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  • 5
    Online Resource
    Online Resource
    BMJ ; 2019
    In:  Journal of the Royal Army Medical Corps Vol. 165, No. 6 ( 2019-12), p. 410-415
    In: Journal of the Royal Army Medical Corps, BMJ, Vol. 165, No. 6 ( 2019-12), p. 410-415
    Abstract: Despite all local authorities in England signing up to the Armed Forces Covenant, only a small proportion of Joint Strategic Needs Assessments (JSNAs) include detailed consideration of the health of the local ex-military population. This article supports improvements to JSNAs by systematically reviewing published research for evidence of differences in health between the ex-military population and the general public. Methods Systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology for qualitative synthesis of mixed study designs. SCOPUS, PubMed and Google Scholar were searched for published research on health outcomes among UK ex-military populations. All study designs were included. Results 43 studies met the inclusion criteria. Rates of mental illness and hearing loss are higher among ex-military populations compared with the general public, while rates of cancer among ex-military personnel born after 1960 are lower. Despite high rates of hazardous drinking among serving personnel, rates of alcohol-related harm among ex-military populations are no higher than the general public. There is a subpopulation at increased risk of a range of adverse outcomes. This group is variously identified as younger, male, less educated, more likely to have served in a combat role and/or left service early. Conclusions This review found evidence of areas of increased and reduced disease burden among ex-military populations. More detailed information on the make-up of the local ex-service population would support more meaningful needs assessments. The Ministry of Defence and local authorities and service providers should work together to support early identification and targeted support for those at the highest risk of adverse outcomes.
    Type of Medium: Online Resource
    ISSN: 0035-8665 , 2052-0468
    Language: English
    Publisher: BMJ
    Publication Date: 2019
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  • 6
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2020
    In:  Journal of Public Health Vol. 42, No. 4 ( 2020-11-23), p. 772-777
    In: Journal of Public Health, Oxford University Press (OUP), Vol. 42, No. 4 ( 2020-11-23), p. 772-777
    Abstract: The English Indices of Multiple Deprivation (IMD) is widely used as a measure of deprivation. However, similarly ranked areas can differ substantially in the underlying domains of deprivation. These domains contain a richer set of data that might be useful for classifying local authorities. Clustering methods offer a set of techniques to identify groups of areas with similar patterns of deprivation. Methods Hierarchical agglomerative (i.e. bottom-up) clustering methods were applied to domain scores for 152 upper tier local authorities. Advances in statistical testing allow clusters to be identified that are unlikely to have arisen from random partitioning of a homogeneous group. The resulting clusters are described in terms of their subdomain scores and basic geographic and demographic characteristics. Results Five statistically significant clusters of local authorities were identified. These clusters only partially reflect different levels of overall deprivation. In particular, two clusters share similar overall IMD scores but have contrasting patterns of deprivation. Conclusion Hierarchical clustering methods identify five distinct clusters that do not correspond closely to quintiles of deprivation. This approach may help to distinguish between places that face similar underlying challenges, and places that appear similar in terms of overall deprivation scores, but that face different challenges.
    Type of Medium: Online Resource
    ISSN: 1741-3842 , 1741-3850
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1497445-9
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  • 7
    Online Resource
    Online Resource
    American Animal Hospital Association ; 2005
    In:  Journal of the American Animal Hospital Association Vol. 41, No. 2 ( 2005-03-01), p. 81-91
    In: Journal of the American Animal Hospital Association, American Animal Hospital Association, Vol. 41, No. 2 ( 2005-03-01), p. 81-91
    Abstract: This paper provides a working framework for enhancing the well-being of senior pet dogs and cats. Approaches to screening the medical status of senior pets are described in detail, with particular emphasis on establishing baseline data in healthy animals, the testing of clinically ill animals, and assessing senior pets prior to anesthesia and surgery. The management of pain and distress and the application of hospice and palliative care are addressed. Advice on ways to approach euthanasia and dealing with end-of-life issues is also provided.
    Type of Medium: Online Resource
    ISSN: 0587-2871 , 1547-3317
    Language: English
    Publisher: American Animal Hospital Association
    Publication Date: 2005
    SSG: 22
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  • 8
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 2020
    In:  The British Journal of Psychiatry Vol. 216, No. 1 ( 2020-01), p. 4-5
    In: The British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 216, No. 1 ( 2020-01), p. 4-5
    Abstract: By protecting vulnerable people from poverty and debt, welfare systems can be powerful tools for promoting mental health. However, the details of how welfare systems are implemented determine whether they also cause harm. Here, we review evidence and principles that might guide the development of mental health-promoting welfare systems.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2020
    detail.hit.zdb_id: 2021500-9
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  • 9
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2023
    In:  Journal of Public Health Vol. 45, No. 3 ( 2023-08-28), p. e409-e416
    In: Journal of Public Health, Oxford University Press (OUP), Vol. 45, No. 3 ( 2023-08-28), p. e409-e416
    Abstract: Contact tracing was central to England’s approach to controlling coronavirus disease 2019 (COVID-19). England’s COVID-19 contact tracing system included a step where cases were invited to provide information through an online ‘self-service’ portal. It is important to understand whether this had any effect on the numbers of contacts reported. Methods This study analyses contact tracing data for one local authority in England for 2021. Univariable negative binomial and logistic regression models were used to test for associations between contact tracing tier and average numbers of contacts reported, and key demographic factors and date of reporting. The association between contact tracing tier and number of contacts reported adjusted for age, gender, ethnicity, deprivation and the date on which the case was reported was estimated using a multivariable negative binomial generalized additive regression model with smooth terms for date of reporting and age. Results Controlling for age, gender, ethnicity, deprivation and date of reporting, self-completed contact tracing was associated with reporting 23% fewer contacts (95% confidence interval 20–25% fewer contacts). Conclusion The use of online self-completed contact tracing may contribute to under-reporting of close contacts. Unmeasured confounding is likely so caution is needed in assuming that the results reflect a causal relationship.
    Type of Medium: Online Resource
    ISSN: 1741-3842 , 1741-3850
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1497445-9
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  • 10
    Online Resource
    Online Resource
    Public Library of Science (PLoS) ; 2022
    In:  PLOS ONE Vol. 17, No. 3 ( 2022-3-10), p. e0263797-
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2022-3-10), p. e0263797-
    Abstract: Refugees, and other forcibly displaced people, face mental distress and may be disproportionately affected by risk factors for suicide. Little is known about suicidal behaviour in these highly mobile populations because collecting timely, relevant, and reliable data is challenging. Methods and findings A systematic review was performed to identify studies of any design reporting on suicide, suicide attempts, or suicidal ideation among populations of displaced people. A sensitive electronic database search was performed in August 2020, and all retrieved studies were screened for relevance by two authors. Studies were categorised by the population being evaluated: refugees granted asylum, refugees living in temporary camps, asylum seekers, or internally displaced people. We distinguished between whether the sampling procedure in the studies was likely to be representative, or the sample examined a specific non-representative subgroup of displaced people (such as those already diagnosed with mental illness). Data on the rates of suicide or the prevalence of suicide attempts or suicidal ideation were extracted by one reviewer and verified by a second reviewer from each study and converted to common metrics. After screening 4347 articles, 87 reports of 77 unique studies were included. Of these, 53 were studies in representative samples, and 24 were based on samples of specific target populations. Most studies were conducted in high-income countries, and the most studied population subgroup was refugees granted asylum. There was substantial heterogeneity across data sources and measurement instruments utilised. Sample sizes of displaced people ranged from 33 to 196,941 in studies using general samples. Suicide rates varied considerably, from 4 to 290 per 100,000 person-years across studies. Only 8 studies were identified that compared suicide rates with the host population. The prevalence of suicide attempts ranged from 0.14% to 15.1% across all studies and varied according to the prevalence period evaluated. Suicidal ideation prevalence varied from 0.17% to 70.6% across studies. Among refugees granted asylum, there was evidence of a lower risk of suicide compared with the host population in 4 of 5 studies. In contrast, in asylum seekers there was evidence of a higher suicide risk in 2 of 3 studies, and of a higher risk of suicidal ideation among refugees living in camps in 2 of 3 studies compared to host populations. Conclusion While multiple studies overall have been published in the literature on this topic, the evidence base is still sparse for refugees in camps, asylum seekers, and internally displaced people. Less than half of the included studies reported on suicide or suicide attempt outcomes, with most reporting on suicidal ideation. International research networks could usefully define criteria, definitions, and study designs to help standardise and facilitate more research in this important area. Registration PROSPERO CRD42019137242.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2022
    detail.hit.zdb_id: 2267670-3
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