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  • 1
    Online Resource
    Online Resource
    Small Angle Neutron Scattering in Drug Discovery Research: A Novel Tool for Advanced Study of Structures of Biological Macromolecules
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Drug Discovery Technologies Vol. 20, No. 5 ( 2023-09)
    Details
    In: Current Drug Discovery Technologies, Bentham Science Publishers Ltd., Vol. 20, No. 5 ( 2023-09)
    Abstract: Small Angle Neutron Scattering (SANS) is a powerful and novel tool for the study of soft condensed matter, including the microscopic and nanomaterials used for drug discovery and delivery. The sample is exposed to a neutron beam, and neutron scattering occurs, which is studied as a function of the scattering angle to deduce a variety of information about the dynamics and structure of the material. The technique is becoming very popular in biomedical research to investigate the various aspects of structural biology. The low-resolution information on large heterogeneous, solubilized biomacromolecular complexes in solution is obtained with the use of deuterium labelling and solvent contrast variation. The article reviews the basics of the SANS technique, its applications in drug delivery research, and its current status in biomedical research. The article covers and overviews the precise characterization of biological structures (membranes, vesicles, proteins in solution), mesoporous structures, colloids, and surfactants, as well as cyclodextrin complexes, lipid complexes, polymeric nanoparticles, etc., with the help of neutron scattering. SANS is continuously evolving as a medium for exploring the complex world of biomolecules, providing information regarding the structure, composition, and arrangement of various constituents. With improving modelling software automation in data reduction and the development of new neutron research facilities, SANS can be expected to remain mainstream for biomedical research.
    Type of Medium: Online Resource
    ISSN: 1570-1638
    URL: Article
    DOI: 10.2174/1570163820666230515162614
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Techniques for the discovery and evaluation of drugs against alopecia
    Informa UK Limited ; 2011
    In:  Expert Opinion on Drug Discovery Vol. 6, No. 3 ( 2011-03), p. 309-321
    Details
    In: Expert Opinion on Drug Discovery, Informa UK Limited, Vol. 6, No. 3 ( 2011-03), p. 309-321
    Type of Medium: Online Resource
    ISSN: 1746-0441 , 1746-045X
    URL: Article
    DOI: 10.1517/17460441.2011.553831
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2272966-5
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Preparation and Characterization of Gastroretentive Floating Microspheres of Ofloxacin Hydrochloride
    BSP Books Private Limited ; 2010
    In:  International Journal of Pharmaceutical Sciences and Nanotechnology Vol. 3, No. 1 ( 2010-05-31), p. 819-823
    Details
    In: International Journal of Pharmaceutical Sciences and Nanotechnology, BSP Books Private Limited, Vol. 3, No. 1 ( 2010-05-31), p. 819-823
    Abstract: As Ofloxacin is preferably absorbed from the upper part of the gastrointestinal tract and is readily soluble in the acidic environment of the stomach, the floating microspheres of ofloxacin were formulated to develop gastroretentive formulation. These floating microspheres release the drug in the stomach and upper gastrointestinal tract and thereby improve the bioavailability. In the present study, six formulations of ofloxacin hydrochloride were prepared as floating microspheres by solvent diffusion technique using polymers such as ethyl cellulose, polyvinyl pyrrolidone K-90 and poly vinyl alcohol in different ratios. The prepared microspheres were evaluated for different physicochemical tests such as particle size, percent drug entrapment, drug content uniformity, SEM, buoyancy test, and in vitro drug release studies. The results of all the physicochemical tests of all formulations were found to be satisfactory. In vitro floatability studies revealed that most of the microspheres (52.5% to 95.5%) were floatable. The in vitro drug release was found to be in the range of 39.64 to 93.64 % at the end of 6 hours. It is concluded that these floating microspheres can be selected for the development of gastroretentive drug delivery system of ofloxacin hydrochloride for potential therapeutic uses.
    Type of Medium: Online Resource
    ISSN: 0974-3278
    URL: Article
    DOI: 10.37285/ijpsn.2010.3.1.4
    Language: Unknown
    Publisher: BSP Books Private Limited
    Publication Date: 2010
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  • 4
    Online Resource
    Online Resource
    Development of Mucoadhesive Buccal Films of Glipizide
    BSP Books Private Limited ; 1970
    In:  International Journal of Pharmaceutical Sciences and Nanotechnology Vol. 1, No. 2 ( 1970-01-01), p. 177-183
    Details
    In: International Journal of Pharmaceutical Sciences and Nanotechnology, BSP Books Private Limited, Vol. 1, No. 2 ( 1970-01-01), p. 177-183
    Abstract: For improving bioavailability in controlled release fashion and to circumvent the hepatic first pass effect of glipizide mucoadhesive buccal films of glipizide were prepared by solvent casting technique. Buccal films were prepared using hydroxy propylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Films were evaluated for their weight, thickness, surface pH, swelling index,       in vitro residence time, folding endurance, in vitro release, ex vivo permeation studies and drug content uniformity. The films exhibited controlled release over more than 6 h. From the study it was concluded that the films containing 5 mg glipizide in 4.9 % w/v hydroxy propylmethylcellulose and 1.5 % w/v sodium carboxymethylcellulose exhibited satisfactory swelling, an optimum residence time and promising drug release thus proved to be potential candidate for the development of buccal films for therapeutic use.
    Type of Medium: Online Resource
    ISSN: 0974-3278
    URL: Article
    DOI: 10.37285/ijpsn.2008.1.2.10
    Language: Unknown
    Publisher: BSP Books Private Limited
    Publication Date: 1970
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  • 5
    Online Resource
    Online Resource
    Supramolecular phospholipids–polyphenolics interactions: The PHYTOSOME® strategy to improve the bioavailability of phytochemicals
    Elsevier BV ; 2010
    In:  Fitoterapia Vol. 81, No. 5 ( 2010-7), p. 306-314
    Details
    In: Fitoterapia, Elsevier BV, Vol. 81, No. 5 ( 2010-7), p. 306-314
    Type of Medium: Online Resource
    ISSN: 0367-326X
    URL: Article
    DOI: 10.1016/j.fitote.2009.11.001
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 2027649-7
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  • 6
    Online Resource
    Online Resource
    Hair growth and rejuvenation: An overview
    Informa UK Limited ; 2011
    In:  Journal of Dermatological Treatment Vol. 22, No. 3 ( 2011-06-01), p. 123-132
    Details
    In: Journal of Dermatological Treatment, Informa UK Limited, Vol. 22, No. 3 ( 2011-06-01), p. 123-132
    Type of Medium: Online Resource
    ISSN: 0954-6634 , 1471-1753
    URL: Article
    DOI: 10.3109/09546630903578574
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2020351-2
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  • 7
    Online Resource
    Online Resource
    Iontophoretic drug delivery system: A review
    IOS Press ; 2007
    In:  Technology and Health Care Vol. 15, No. 4 ( 2007-07-01), p. 237-245
    Details
    In: Technology and Health Care, IOS Press, Vol. 15, No. 4 ( 2007-07-01), p. 237-245
    Type of Medium: Online Resource
    ISSN: 0928-7329 , 1878-7401
    URL: Article
    DOI: 10.3233/THC-2007-15402
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2007
    detail.hit.zdb_id: 2043772-9
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  • 8
    Online Resource
    Online Resource
    CELLULOSE ACETATE FLOATING MICROSPHERES OF METFORMIN HYDROCHLORIDE: FORMULATION AND CHARACTERIZATION
    Indian Drug Manufacturers' Association (IDMA) ; 2021
    In:  INDIAN DRUGS Vol. 57, No. 12 ( 2021-04-20), p. 65-69
    Details
    In: INDIAN DRUGS, Indian Drug Manufacturers' Association (IDMA), Vol. 57, No. 12 ( 2021-04-20), p. 65-69
    Abstract: In this study, floating microspheres of metformin hydrochloride were prepared by using cellulose acetate polymer by solvent evaporation method. Four formulations were prepared by varying the ratio of drug and polymer. The prepared microspheres were then subjected to various evaluation parameters such as drug content, micromeritic evaluations, FTIR, SEM, floatability and in vitro dissolution study. Formulation F1 (1:1 ratio of polymer and drug) showed the highest drug release and drug content with good flow properties. The cumulative percentage of drug release significantly decreased with decreasing drug concentration with a constant polymer ratio. Scanning Electron Microscopy images of all formulations showed that the prepared floating microspheres were irregular in shape, and the surface was found to be non- uniform and rough. In vitro release studies indicated the mechanism of the drug release to follow the Korsemeyer-Peppas model, and “n” value was found to be between 0.54-1.89, indicating anomalous transport mechanism.
    Type of Medium: Online Resource
    ISSN: 0019-462X
    URL: Journal
    URL: Article
    DOI: 10.53879/id
    DOI: 10.53879/id.57.12.12742
    Language: Unknown
    Publisher: Indian Drug Manufacturers' Association (IDMA)
    Publication Date: 2021
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Antiobesity Drug Discovery Research: in vitro Models for Shortening the Drug Discovery Pipeline
    Bentham Science Publishers Ltd. ; 2024
    In:  Current Drug Targets Vol. 25 ( 2024-03-18)
    Details
    In: Current Drug Targets, Bentham Science Publishers Ltd., Vol. 25 ( 2024-03-18)
    Abstract: Obesity is a growing global health problem, leading to various chronic diseases. Despite standard treatment options, the prevalence of obesity continues to rise, emphasizing the need for new drugs. in vitro methods of drug discovery research provide a time and cost-saving platform to identify new antiobesity drugs. The review covers various aspects of obesity and drug discovery research using in vitro models. Besides discussing causes, diagnosis, prevention, and treatment, the review focuses on the advantages and limitations of in vitro studies and exhaustively covers models based on enzymes and cell lines from different animal species and humans. In contrast to conventional in vivo animal investigations, in vitro preclinical tests using enzyme- and cell line-based assays provide several advantages in development of antiobesity drugs. These methods are quick, affordable, and provide high-throughput screening. They can also yield insightful information about drug-target interactions, modes of action, and toxicity profiles. By shedding light on the factors that lead to obesity, in vitro tests can also present a chance for personalized therapy. Technology will continue to evolve, leading to the creation of more precise and trustworthy in vitro assays, which will become more and more crucial in the search for novel antiobesity medications.
    Type of Medium: Online Resource
    ISSN: 1389-4501
    URL: Article
    DOI: 10.2174/0113894501289136240312060838
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2024
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Natural Macromolecules in the Development of Safe and Effective Gastroretentive Floating Microparticles of Metformin Hydrochloride
    Bentham Science Publishers Ltd. ; 2016
    In:  The Natural Products Journal Vol. 6, No. 1 ( 2016-03), p. 62-72
    Details
    In: The Natural Products Journal, Bentham Science Publishers Ltd., Vol. 6, No. 1 ( 2016-03), p. 62-72
    Abstract: Metformin hydrochloride, an oral hypoglycaemic, shows better absorption from upper part of the gastric region. Natural/herbal substances have been investigated for the development of natural polymer-based drug delivery systems owing to the desirable properties like biodegradability, biocompatibility, aqueous solubility, swelling ability, easy availability and cost effectiveness. Method: Therefore, three natural macromolecules: Glycine max (soya chunks), Metroxylon sagu (sago starch) and Plantago ovata (psyllium husk) were used for developing its gastroretentive floating microparticles for expected improvement in bioavailability. The macromolecules and the prepared microparticles were evaluated for physicochemical properties, FTIR, XRPD, DSC and dug release. Result: The percent drug content was in the range of 60.353 ± 1.25 to 92.682 ± 2.47 % for all the microparticles. All the formulations showed good swelling and floating properties (the formulation prepared with P. ovata showed the best swelling and in vitro floatability). The FTIR studies showed that the herbal carriers were compatible with the drug. XRD and DSC studies showed a transition in the physical state of the drug in the formulations from crystalline state to amorphous state. In vitro drug release studies showed good percent cumulative drug release from all the formulations (72.13 to 87.06 % at the end of 6 hour) with non-fickian diffusion process. Conclusion: Therefore, it was concluded that the herbal macromolecules may be the potential, safe and effective carriers for improving the drug delivery of the metformin like drugs by developing, effective gastroretentive floating drug delivery systems.
    Type of Medium: Online Resource
    ISSN: 2210-3155
    URL: Article
    DOI: 10.2174/2210315506999151209101058
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2016
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