In:
Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 222, No. 1 ( 2003-01-01), p. 37-41
Abstract:
Objective —To determine sedative and cardiorespiratory
effects of dexmedetomidine alone and in combination with butorphanol or ketamine in cats. Design —Randomized crossover study. Animals —6 healthy adult cats. Procedures —Cats were given dexmedetomidine
alone (10 μg/kg [4.5 mg/lb] , IM), a combination of
dexmedetomidine (10 μg/kg, IM) and butorphanol (0.2 mg/kg [0.09 mg/lb], IM), or a combination of dexmedetomidine (10 μg/kg, IM) and ketamine (5
mg/kg [2.3 mg/lb] , IM). Treatments were administered
in random order, with ≥ 1 week between treatments. Physiologic variables were assessed before
and after drug administration. Time to lateral recumbency, duration of lateral recumbency, time to sternal
recumbency, time to recovery from sedation, and subjective evaluation of sedation, muscle relaxation,
and auditory response were assessed. Results —Each treatment resulted in adequate sedation;
time to lateral recumbency, duration of lateral recumbency, and time to recovery from sedation
were similar among treatments. Time to sternal recumbency was significantly greater after administration
of dexmedetomidine-ketamine. Heart rate decreased significantly after each treatment; however,
the decrease was more pronounced after administration of dexmedetomidine-butorphanol, compared
with that following the other treatments. Systolic and diastolic blood pressure measurements decreased
significantly from baseline with all treatments; 50 minutes after drug administration, mean blood pressure
differed significantly from baseline only when cats received dexmedetomidine and butorphanol. Conclusions and Clinical Relevance —Results suggested
that in cats, administration of dexmedetomidine combined with butorphanol or ketamine resulted
in more adequate sedation, without clinically important cardiovascular effects, than was achieved with
dexmedetomidine alone. ( J Am Vet Med Assoc 2003;222:37–41)
Type of Medium:
Online Resource
ISSN:
0003-1488
DOI:
10.2460/javma.2003.222.37
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2003
detail.hit.zdb_id:
2904887-4
SSG:
22
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