In:
The Journal of Immunology, The American Association of Immunologists, Vol. 121, No. 3 ( 1978-09-01), p. 863-865
Abstract:
Proliferation of human lymphocytes induced by IO4- is potentiated by 30 min exposure to colchicine (10-6 M), whereas the response to Con A is inhibited. Treatment with colchicine before or after IO4- modification has similar enhancing effects. Lumicolchicine does not alter proliferative responses. In addition to the proliferation of IO4--oxidized cells, irradiated IO4--modified lymphocytes induce proliferation when mixed with untreated lymphocytes. Enhancement occurs in both these conditions only when IO4--modified cells are treated with colchicine. Preliminary data indicate that proliferation in mixed lymphocyte cultures is also potentiated when either stimulating or responding cells are pretreated with colchicine. These findings suggest a selective stimulatory effect of colchicine on lymphocyte responses induced by cell-cell contact. Agents that modify microtubular assemblies might regulate the induction of immune responses that involve cellular interactions.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.121.3.863
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1978
detail.hit.zdb_id:
1475085-5
detail.hit.zdb_id:
3056-9
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