In:
Heteroatom Chemistry, Wiley, Vol. 13, No. 1 ( 2002-01), p. 77-83
Abstract:
The efficient syntheses of two new types of conformationally constrained S‐[2‐[(1‐iminoethyl)amino]ethyl] homocysteine derivatives, 1‐amino‐3‐[2[(1‐iminoethyl)amino]ethylthio] cyclobutane carboxylic Acid ( 5 ) and (4S)‐4‐[[2‐[(1‐Iminoethyl)amino]ethyl] thio]‐L‐proline ( 6 ), are reported. These molecules represent the first attempts to probe conformational constraint near the α‐amino acid moiety of known homocysteine‐based inhibitors of nitric oxide synthase. Targets 5 and 6 were evaluated as potential inhibitors of the three human isoforms of nitric oxide synthase. © 2002 John Wiley & Sons, Inc. Heteroatom Chem 13:77–83, 2002; DOI 10.1002/hc.1109
Type of Medium:
Online Resource
ISSN:
1042-7163
,
1098-1071
Language:
English
Publisher:
Wiley
Publication Date:
2002
detail.hit.zdb_id:
1483690-7
detail.hit.zdb_id:
1014910-7
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