In:
Zeitschrift für Naturforschung B, Walter de Gruyter GmbH, Vol. 31, No. 6 ( 1976-6-1), p. 832-845
Abstract:
cis-Dichlorodipeptide esterplatinum complexesCl 2 Pt(MetGlyOEt),Cl 2 Pt(EthionylGlyOEt), Cl 2 Pt(GlyGlyOEt)2 and Cl 2 Pt(GlySerOEt) 2 are prepared from the α-amino acid complexes by peptide synthesis using platinum as an amino protecting group. cis-Cl 2 Pt(GlyGlyOEt)2 and cis-Cl 2 Pt(GlySerOEt)2 have been prepared also directly from K 2 PtCl 4 and the dipeptidesters. cis-Cl 2 Pt(GlyGlyOEt) 2 (2 a) and cis-Cl 2 Pt(NH 3 ) 2 (5) lead to a prefered inhibition of the DNA-synthesis of sarcoma 180, Yoshida-sarcoma and Walker-256-carcinosarcoma in vitro; RNA- and protein biosynthesis are influenced to a much lower degree. 2a and 5 cause filamentous growth in Escherichia coli B. The DNA polymerase deficient strain of E. coli, p 3478 pol A-, is more inhibited by 2 a and 5 than the non deficient strain W 3110 pol A + . Tumor growth of di-2-chloro-ethylmethylamine (HN 2 ) resistant sarcoma 180 and of Yoshida sarcoma is weakly inhibited, whereas Walker-256-carcinosarcoma is markedly inhibited; however 2a and 5 show similar inhibition of the same tumor.
Type of Medium:
Online Resource
ISSN:
1865-7117
,
0932-0776
DOI:
10.1515/znb-1976-0623
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1976
detail.hit.zdb_id:
2078109-X
detail.hit.zdb_id:
124635-5
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