In:
Bioelectromagnetics, Wiley, Vol. 27, No. 3 ( 2006-04), p. 221-225
Abstract:
The study explored the effect of ambient oxygen on mammalian cell survival after exposure to 10 ns duration, high voltage electrical pulses (nsEP, 80–90 or 120–130 kV/cm; 200–400 pulses per exposure). Cell samples were equilibrated with pure nitrogen, atmospheric air, or pure oxygen prior to the nsEP treatment and were returned to the incubator (air + 5% CO 2 ) shortly after the exposure. The experiments established that survival of hypoxic Jurkat and U937 cells exceeded that of air‐equilibrated controls about twofold ( P 〈 .01). Conversely, saturation of the medium with oxygen prior to exposure decreased Jurkat cell survival about 1.5 times, P 〈 .01. Attenuation of the cytotoxic effect under hypoxic conditions resembled a well‐known effect of oxygen on cell killing by sparsely ionizing radiations and may be indicative of the similarity of underlying cell damage mechanisms. Bioelectromagnetics 27:221–225, 2006. Published 2005 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0197-8462
,
1521-186X
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2001228-7
SSG:
12
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