In:
NMR in Biomedicine, Wiley, Vol. 27, No. 10 ( 2014-10), p. 1184-1191
Kurzfassung:
The purpose of this study was to correlate intravoxel incoherent motion (IVIM) imaging with classical perfusion‐weighted MRI metrics in human gliomas. Parametric images for slow diffusion coefficient ( D ), fast diffusion coefficient ( D *), and fractional perfusion‐related volume ( f ) in patients with high‐grade gliomas were generated. Maps of F p (plasma flow), v p (vascular plasma volume), PS (permeability surface–area product), v e (extravascular, extracellular volume), E (extraction ratio), k e (influx ratio into the interstitium), and t c (vascular transit time) from dynamic contrast‐enhanced (DCE) and dynamic susceptibility contrast‐enhanced (DSC) MRI were also generated. A region‐of‐interest analysis on the contralateral healthy white matter and on the tumor areas was performed and the extracted parameter values were tested for any significant differences among tumor grades or any correlations. Only f could be significantly correlated to DSC‐derived v p and t c in healthy brain tissue. Concerning the tumor regions, F p was significantly positively correlated with D * and inversely correlated with f in DSC measurements. The D *, f , and f × D * values in the WHO grade III gliomas were non‐significantly different from those in the grade IV gliomas. There was a trend to significant negative correlations between f and PS as well as between f × D * and k e in DCE experiments. Presumably due to different theoretical background, tracer properties and modeling of the tumor vasculature in the IVIM theory, there is no clearly evident link between D *, f and DSC‐ and DCE‐derived metrics. Copyright © 2014 John Wiley & Sons, Ltd.
Materialart:
Online-Ressource
ISSN:
0952-3480
,
1099-1492
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2002003-X
ZDB Id:
1000976-0
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