In:
Neurogastroenterology & Motility, Wiley, Vol. 17, No. 6 ( 2005-12), p. 871-877
Abstract:
Abstract When injected intracerebroventricularly (i.c.v.) in rats, nociceptin/orphanin FQ (N/OFQ) delays gastric emptying and increases plasma corticosterone levels. Our aim in this study was to investigate changes in gastric emptying of a phenol red meal, and the plasma corticosterone response to N/OFQ in adrenalectomized (ADX) rats, in ADX rats injected with corticosterone at 1, 24 and 72 h before the gastric emptying assay, and in intact rats i.c.v. pretreated with a glucocorticoid antagonist (RU486) and with a corticotropin‐releasing factor receptor antagonist ( α ‐helical CRF 9–41 ). In adrenal intact rats, i.c.v. injection of N/OFQ (2.5 nmol rat −1 ) significantly delayed gastric emptying (by 70%) and increased plasma corticosterone concentrations. Conversely, in ADX rats, N/OFQ left gastric emptying unchanged. In ADX rats, corticosterone injected at 1, 24 and 72 h before the gastric emptying assay almost restored the N/OFQ‐induced delay in gastric emptying. Finally, pretreatment with RU486‐ and α ‐helical CRF 9–41 abolished the N/OFQ‐induced inhibition of gastric emptying. These findings suggest that central N/OFQ inhibits gastric emptying through an integrated orphaninergic system–CRF interaction in which corticosterone plays a permissive role.
Type of Medium:
Online Resource
ISSN:
1350-1925
,
1365-2982
DOI:
10.1111/nmo.2005.17.issue-6
DOI:
10.1111/j.1365-2982.2005.00717.x
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2008278-2
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