GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Abstract 2809: Deficiency of Notch-1 signaling in liver increases neuroblastoma hepatic metastases.
    American Association for Cancer Research (AACR) ; 2013
    In:  Cancer Research Vol. 73, No. 8_Supplement ( 2013-04-15), p. 2809-2809
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 73, No. 8_Supplement ( 2013-04-15), p. 2809-2809
    Abstract: Purpose: The Notch signaling pathway has been extensively studied for its role in tumor angiogenesis but its function in tumor metastasis is largely elusive. In the present study we investigated the role of a notch receptor, Notch-1, in the regulation of neuroblastoma liver metastatic process. Methods: To investigate the function of Notch-1 in neuroblastoma liver metastasis we first generated immunodeficient (rag2gammaC deletion) Notch-1 heterozygous (+/-) mice. We crossed a Notch1 heterozygous (+/-) mouse with a rag2/gamma-c double knockout (-/-) mouse. The mouse with Notch1(+/-)rag2(+/-)gammaC(+/-) genotype was then backcrossed with a rag2gammaC double knockout (-/-) mouse to generate rag2(-/-)gammaC(-/-)Notch1(+/-) mouse or rag2(-/-)gammaC(-/-)Notch1(+/+)control mouse . These mice (n=5) were intracardically injected with 105 neuroblastoma NGP (MYCN amplified) cells expressing Firefly luciferase. The mice were subjected to IVIS- bioluminescence imaging, once in a week, to monitor the metastatic spread. All mice were sacrificed at week 8. At the time of sacrifice, mice were injected with Luciferin, sacrificed and liver was then dissected out, imaged and bioluminescence flux was measured (ex vivo imaging). The liver tissues were also sectioned (5um, paraffin) and H & E stained at multiple levels to further confirm the presence of metastases. Result: Intracardically injected NGP cells formed increased liver metastases in rag2(-/-)gammaC(-/-)Notch1(+/-) mice compared to littermate control rag2(-/-)gammaC(-/-)Notch1(+/+) mice. 4 out of 5 (80%) mice in Notch-het group and only 1 out of 5 (20%) mice in control group developed hepatic metastases. Notch-het livers showed multiple metastatic lesions with diameter ranged from 1-5 mm. Ex vivo bioluminescence imaging showed total flux (photon/sec) of Notch1 (+/-) livers were significantly higher (p & lt;0.01) compared to Notch1 (+/+) control livers. Immunohistochemical staining against blood vessel markers such as Collagen IV, endomucin (endothelial cells) and aSMA (pericyte) showed extensive network of angiogenesis in Notch1 (+/-) liver metastases. Conclusion: Deficiency of Notch1 signaling in liver microenvironment presented an increase in metastases in Notch-het mice in NGP intracardiac injection metastatic model. Therefore our study indicates that Notch1 acts as tumor suppressor in neuroblastoma liver metastasis. Citation Format: Debarshi Banerjee, Alejandro Garcia, John Andrews, Emily Sbiroli, Jessica J. Kandel, Darrel J. Yamashiro. Deficiency of Notch-1 signaling in liver increases neuroblastoma hepatic metastases. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2809. doi:10.1158/1538-7445.AM2013-2809
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2013-2809
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2013
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Inhibition of host Notch function disrupts hepatic vasculature, and promotes tumor growth
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Journal of the American College of Surgeons Vol. 215, No. 3 ( 2012-09), p. S70-S71
    Details
    In: Journal of the American College of Surgeons, Ovid Technologies (Wolters Kluwer Health), Vol. 215, No. 3 ( 2012-09), p. S70-S71
    Type of Medium: Online Resource
    ISSN: 1072-7515
    URL: Article
    DOI: 10.1016/j.jamcollsurg.2012.06.195
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Coding for climate: sourcing better climate-health data from medical billing
    IOP Publishing ; 2023
    In:  Environmental Research: Health Vol. 1, No. 2 ( 2023-06-01), p. 021008-
    Details
    In: Environmental Research: Health, IOP Publishing, Vol. 1, No. 2 ( 2023-06-01), p. 021008-
    Abstract: While evidence points to climate change adversely impacting health and wellbeing, there remains a great need for more authoritative and actionable data that better describes the full magnitude and scope of this growing crisis. Given the uncertainty inherent to current detection and attribution studies, the improved specificity offered by the 10th revision of the International Classification of Diseases (ICD-10) coding of climate-sensitive health outcomes at the point of care may help to better quantify the connection between more intense and frequent extreme weather events and specific health sequela. With improved application of the available ICD-10 codes designed to capture climate-sensitive health outcomes, the ICD-10 system can function as a leading indicator. In this collaboration, publicly available ICD-10 code data was downloaded from Centers for Medicare and Medicaid Services archives and cross-referenced with 29 keywords (e.g. heat, hurricane, smoke, etc) determined by relevance to climate impacts on human health from consensus literature. We identified 46 unique ICD-10 codes for climate-sensitive health conditions. By highlighting the need for broader application of these codes and advocating for the development of new codes that better document the growing burden of climate-sensitive health outcomes, we hope to drive the development of more evidence-based, health-protective interdisciplinary climate action strategies across health systems.
    Type of Medium: Online Resource
    ISSN: 2752-5309
    URL: Article
    DOI: 10.1088/2752-5309/acc887
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Risk Factors for Peri-intubation Cardiac Arrest in a Pediatric Emergency Department
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Pediatric Emergency Care Vol. 38, No. 1 ( 2022-1), p. e126-e131
    Details
    In: Pediatric Emergency Care, Ovid Technologies (Wolters Kluwer Health), Vol. 38, No. 1 ( 2022-1), p. e126-e131
    Abstract: Cardiac arrest is a significant complication of emergent endotracheal intubation (ETI) within the pediatric population. No studies have evaluated risk factors for peri-intubation cardiac arrest (PICA) in a pediatric emergency department (ED) setting. This study identified risk factors for PICA among patients undergoing emergent ETI in a pediatric ED. Methods We performed a nested case-control study within the cohort of children who underwent emergent ETI in our pediatric ED during a 9-year period. Cases were children with PICA within 20 minutes of ETI. Controls (4 per case) were randomly selected children without PICA after ETI. We analyzed potential risk factors based on published data and physiologic plausibility and created a simple risk model using univariate results, model fit statistics, and clinical judgment. Results In the cohort of patients undergoing ETI, PICA occurred in 21 of 543 subjects (3.9%; 95% confidence interval [CI], 2.2–5.9%), with return of spontaneous circulation in 16 of 21 (76.2%; 95% CI, 52.8–91.8%) and survival to discharge in 12 of 21 (57.1%; 95% CI, 34.0–78.2%). On univariate analysis, cases were more likely to be younger, have delayed capillary refill time, systolic or diastolic hypotension, hypoxia, greater than one intubation attempt, no sedative or paralytic used, and pulmonary disease compared with controls. Our 4-category risk model for PICA combined preintubation hypoxia (or an unobtainable pulse oximetry value) and younger than 1 year. The area under the receiver operating characteristic curve for this model was 0.87 (95% CI, 0.77–0.97). Conclusions Hypoxia (or an unobtainable pulse oximetry value) was the strongest predictor for PICA among children after emergent ETI in our sample. A simple risk model combining pre-ETI hypoxia and younger than 1 year showed excellent discrimination in this sample. Our results require independent validation.
    Type of Medium: Online Resource
    ISSN: 1535-1815 , 0749-5161
    URL: Article
    DOI: 10.1097/PEC.0000000000002171
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2053985-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Notch Suppresses Angiogenesis and Progression of Hepatic Metastases
    American Association for Cancer Research (AACR) ; 2015
    In:  Cancer Research Vol. 75, No. 8 ( 2015-04-15), p. 1592-1602
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 8 ( 2015-04-15), p. 1592-1602
    Abstract: The Notch pathway plays multiple key roles in tumorigenesis, and its signaling components have therefore aroused great interest as targets for emerging therapies. Here, we show that inhibition of Notch, using a soluble receptor Notch1 decoy, unexpectedly caused a remarkable increase in liver metastases from neuroblastoma and breast cancer cells. Increased liver metastases were also seen after treatment with the γ-secretase inhibitor PF-03084014. Transgenic mice with heterozygous loss of Notch1 demonstrated a marked increase in hepatic metastases, indicating that Notch1 signaling acts as metastatic suppressor in the liver microenvironment. Inhibition of DLL1/4 with ligand-specific Notch1 decoys increased sprouting of sinusoidal endothelial cells into micrometastases, thereby supporting early metastatic angiogenic growth. Inhibition of tumor-derived JAG1 signaling activated hepatic stellate cells, increasing their recruitment to vasculature of micrometastases, thereby supporting progression to macrometastases. These results demonstrate that inhibition of Notch causes pathologic activation of liver stromal cells, promoting angiogenesis and growth of hepatic metastases. Our findings have potentially serious implications for Notch inhibition therapy. Cancer Res; 75(8); 1592–602. ©2015 AACR.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/0008-5472.CAN-14-1493
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2015
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Heat Waves and Emergency Department Visits Among the Homeless, San Diego, 2012–2019
    American Public Health Association ; 2022
    In:  American Journal of Public Health Vol. 112, No. 1 ( 2022-01), p. 98-106
    Details
    In: American Journal of Public Health, American Public Health Association, Vol. 112, No. 1 ( 2022-01), p. 98-106
    Abstract: Objectives. To determine the effect of heat waves on emergency department (ED) visits for individuals experiencing homelessness and explore vulnerability factors. Methods. We used a unique highly detailed data set on sociodemographics of ED visits in San Diego, California, 2012 to 2019. We applied a time-stratified case–crossover design to study the association between various heat wave definitions and ED visits. We compared associations with a similar population not experiencing homelessness using coarsened exact matching. Results. Of the 24 688 individuals identified as experiencing homelessness who visited an ED, most were younger than 65 years (94%) and of non-Hispanic ethnicity (84%), and 14% indicated the need for a psychiatric consultation. Results indicated a positive association, with the strongest risk of ED visits during daytime (e.g., 99th percentile, 2 days) heat waves (odds ratio = 1.29; 95% confidence interval = 1.02, 1.64). Patients experiencing homelessness who were younger or elderly and who required a psychiatric consultation were particularly vulnerable to heat waves. Odds of ED visits were higher for individuals experiencing homelessness after matching to nonhomeless individuals based on age, gender, and race/ethnicity. Conclusions. It is important to prioritize individuals experiencing homelessness in heat action plans and consider vulnerability factors to reduce their burden. (Am J Public Health. 2022;112(1):98–106. https://doi.org/10.2105/AJPH.2021.306557 )
    Type of Medium: Online Resource
    ISSN: 0090-0036 , 1541-0048
    URL: Article
    DOI: 10.2105/AJPH.2021.306557
    RVK:
    XA 10000
    Language: English
    Publisher: American Public Health Association
    Publication Date: 2022
    detail.hit.zdb_id: 2054583-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Climate change and women's health in the United States: Impacts and opportunities
    Elsevier BV ; 2022
    In:  The Journal of Climate Change and Health Vol. 8 ( 2022-10), p. 100169-
    Details
    In: The Journal of Climate Change and Health, Elsevier BV, Vol. 8 ( 2022-10), p. 100169-
    Type of Medium: Online Resource
    ISSN: 2667-2782
    URL: Article
    DOI: 10.1016/j.joclim.2022.100169
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 3067410-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...